Triazolam and Voriconazole Interaction
Drug interaction information between Triazolam and Voriconazole.
Triazolam and Voriconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Triazolam and Voriconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Voriconazole blocks the enzyme that processes triazolam, which can cause the drug to stay in your system longer. This leads to higher levels of the medication in your blood.
FDA Label Information
Other benzodiazepines including triazolam and alprazolam (CYP3A4 Inhibition) In Vitro Studies Demonstrated Potential for Voriconazole to Inhibit Metabolism (Increased Plasma Exposure) HMG-CoA Reductase Inhibitors (Statins) (CYP3A4 Inhibition) In Vitro Studies Demonstrated Potential for Voriconazole to Inhibit Metabolism (Increased Plasma Exposure) Frequent monitoring for adverse reactions and toxicity related to statins.
Triazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Aprepitant moderate
- Clarithromycin moderate
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Lurasidone major
- Pimozide major
- Ivabradine major
Frequently Asked Questions
What SPL severity band is on file for Triazolam + Voriconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Voriconazole has 50 labeled pairs on file vs Triazolam's 10. In the minor band specifically: Triazolam has 5 (also Diltiazem, Fluconazole, Posaconazole, Tiagabine); Voriconazole has 33 (also Omeprazole, Ibuprofen, Alprazolam, Oxycodone).
What mechanism field is on file for Triazolam and Voriconazole?
Voriconazole blocks the enzyme that processes triazolam, which can cause the drug to stay in your system longer. This leads to higher levels of the medication in your blood.
Voriconazole carries more major-labeled pairs than Triazolam
SPL source-record counts only. This page's band is minor · classes on file: Triazolam (Benzodiazepine (Hypnotic)); Voriconazole (Azole Antifungal).
Voriconazole has 8 major-labeled pairs vs Triazolam's 3. This page itself is in the minor band, not the major band.
3 major · 2 moderate · 5 minor · 10 total
- Other minor peers for Triazolam
- Diltiazem
- Fluconazole
- Posaconazole
- Tiagabine
8 major · 9 moderate · 33 minor · 50 total
- Other minor peers for Voriconazole
- Omeprazole
- Ibuprofen
- Alprazolam
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.