Triazolam and Fluconazole Interaction
Drug interaction information between Triazolam and Fluconazole.
Triazolam and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Triazolam and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole stops your body from breaking down triazolam normally, which can make the drug's effects last longer and feel stronger.
FDA Label Information
Triazolam: Fluconazole increases the AUC of triazolam (single dose) by approximately 50%, C max by 20% to 32%, and increases t ½ by 25% to 50% due to the inhibition of metabolism of triazolam. Dosage adjustments of triazolam may be necessary.
Triazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Aprepitant moderate
- Clarithromycin moderate
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Triazolam + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Triazolam's 10. In the minor band specifically: Triazolam has 5 (also Diltiazem, Posaconazole, Tiagabine, Voriconazole); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Triazolam and Fluconazole?
Fluconazole stops your body from breaking down triazolam normally, which can make the drug's effects last longer and feel stronger.
Fluconazole's labeled portfolio outnumbers Triazolam
SPL source-record counts only. This page's band is minor · classes on file: Triazolam (Benzodiazepine (Hypnotic)); Fluconazole (Azole Antifungal).
3 major · 2 moderate · 5 minor · 10 total
- Other minor peers for Triazolam
- Diltiazem
- Posaconazole
- Tiagabine
- Voriconazole
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.