Voriconazole and Omeprazole Interaction
Drug interaction information between Voriconazole and Omeprazole.
Voriconazole and Omeprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Voriconazole and Omeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Voriconazole stops your body from breaking down omeprazole normally. This leads to much higher levels of omeprazole in your system.
FDA Label Information
Omeprazole (CYP2C19/3A4 Inhibition) Significantly Increased When initiating therapy with VFEND in patients already receiving omeprazole doses of 40 mg or greater, reduce the omeprazole dose by one-half.
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Lurasidone major
- Pimozide major
- Ivabradine major
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
Frequently Asked Questions
What SPL severity band is on file for Voriconazole + Omeprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Voriconazole has 50 labeled pairs on file vs Omeprazole's 27. In the minor band specifically: Voriconazole has 33 (also Ibuprofen, Alprazolam, Oxycodone, Diclofenac); Omeprazole has 22 (also Aripiprazole, Atomoxetine, Brexpiprazole, Carbamazepine).
What mechanism field is on file for Voriconazole and Omeprazole?
Voriconazole stops your body from breaking down omeprazole normally. This leads to much higher levels of omeprazole in your system.
Voriconazole carries more major-labeled pairs than Omeprazole
SPL source-record counts only. This page's band is minor · classes on file: Voriconazole (Azole Antifungal); Omeprazole (Proton Pump Inhibitor (PPI)).
Voriconazole has 8 major-labeled pairs vs Omeprazole's 1. This page itself is in the minor band, not the major band.
8 major · 9 moderate · 33 minor · 50 total
- Other minor peers for Voriconazole
- Ibuprofen
- Alprazolam
- Oxycodone
- Diclofenac
1 major · 4 moderate · 22 minor · 27 total
- Other minor peers for Omeprazole
- Aripiprazole
- Atomoxetine
- Brexpiprazole
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.