Triazolam and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Triazolam and Nirmatrelvir/Ritonavir.
Triazolam and Nirmatrelvir/Ritonavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Triazolam and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Nirmatrelvir/ritonavir prevents your body from breaking down triazolam, leading to much higher levels of the sedative in your blood. This can cause you to become dangerously sleepy or have trouble breathing.
FDA Label Information
Sedative/hypnotics triazolam, oral midazolam ↑ triazolam ↑ midazolam Co-administration contraindicated due to potential for extreme sedation and respiratory depression [see Contraindications (4) ] .
Triazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Aprepitant moderate
- Clarithromycin moderate
- Diltiazem minor
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Triazolam + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Triazolam's 10. In the major band specifically: Triazolam has 3 (also Darunavir, Itraconazole); Nirmatrelvir/Ritonavir has 23 (also Simvastatin, Lovastatin, Sildenafil, Carbamazepine).
What mechanism field is on file for Triazolam and Nirmatrelvir/Ritonavir?
Nirmatrelvir/ritonavir prevents your body from breaking down triazolam, leading to much higher levels of the sedative in your blood. This can cause you to become dangerously sleepy or have trouble breathing.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Triazolam
SPL source-record counts only. This page's band is major · classes on file: Triazolam (Benzodiazepine (Hypnotic)); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Triazolam's 3.
3 major · 2 moderate · 5 minor · 10 total
- Other major peers for Triazolam
- Darunavir
- Itraconazole
23 major · 30 moderate · 33 minor · 86 total
- Other major peers for Nirmatrelvir/Ritonavir
- Simvastatin
- Lovastatin
- Sildenafil
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.