Triazolam and Diltiazem Interaction
Drug interaction information between Triazolam and Diltiazem.
Triazolam and Diltiazem have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Triazolam and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diltiazem slows down how fast your body gets rid of triazolam, which can make the sedative effects last much longer.
FDA Label Information
Benzodiazepines : Studies showed that diltiazem increased the AUC of midazolam and triazolam by 3- to 4-fold and the C max by 2-fold, compared to placebo. The elimination half-life of midazolam and triazolam also increased (1.5- to 2.5-fold) during coadministration with diltiazem. These pharmacokinetic effects seen during diltiazem coadministration can result in increased clinical effects (e.g., prolonged sedation) of both midazolam and triazolam.
Triazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Aprepitant moderate
- Clarithromycin moderate
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Triazolam + Diltiazem?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Triazolam's 10. In the minor band specifically: Triazolam has 5 (also Fluconazole, Posaconazole, Tiagabine, Voriconazole); Diltiazem has 35 (also Buspirone, Pravastatin, Lovastatin, Cyclosporine).
What mechanism field is on file for Triazolam and Diltiazem?
Diltiazem slows down how fast your body gets rid of triazolam, which can make the sedative effects last much longer.
Diltiazem carries more major-labeled pairs than Triazolam
SPL source-record counts only. This page's band is minor · classes on file: Triazolam (Benzodiazepine (Hypnotic)); Diltiazem (Calcium Channel Blocker).
Diltiazem has 4 major-labeled pairs vs Triazolam's 3. This page itself is in the minor band, not the major band.
3 major · 2 moderate · 5 minor · 10 total
- Other minor peers for Triazolam
- Fluconazole
- Posaconazole
- Tiagabine
- Voriconazole
4 major · 7 moderate · 35 minor · 46 total
- Other minor peers for Diltiazem
- Buspirone
- Pravastatin
- Lovastatin
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.