Triazolam and Itraconazole Interaction
Drug interaction information between Triazolam and Itraconazole.
Triazolam and Itraconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Triazolam and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole prevents your body from clearing triazolam, which can make the sleep medicine much more powerful and potentially dangerous.
FDA Label Information
Lurasidone Midazolam (oral) a Pimozide Triazolam a Contraindicated during and 2 weeks after itraconazole treatment.
Triazolam Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Aprepitant moderate
- Clarithromycin moderate
- Diltiazem minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Triazolam + Itraconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Triazolam's 10. In the major band specifically: Triazolam has 3 (also Darunavir, Nirmatrelvir/Ritonavir); Itraconazole has 19 (also Isavuconazonium, Lurasidone, Pimozide, Methadone).
What mechanism field is on file for Triazolam and Itraconazole?
Itraconazole prevents your body from clearing triazolam, which can make the sleep medicine much more powerful and potentially dangerous.
Itraconazole carries more major-labeled pairs than Triazolam
SPL source-record counts only. This page's band is major · classes on file: Triazolam (Benzodiazepine (Hypnotic)); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Triazolam's 3.
3 major · 2 moderate · 5 minor · 10 total
- Other major peers for Triazolam
- Darunavir
- Nirmatrelvir/Ritonavir
19 major · 20 moderate · 77 minor · 116 total
- Other major peers for Itraconazole
- Isavuconazonium
- Lurasidone
- Pimozide
- Methadone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.