What the FDA labels say about taking them together
Alprazolam and voriconazole
Voriconazole's FDA label of February 26, 2026 names alprazolam in its drug interactions section; alprazolam's label does not name voriconazole itself but warns about its class (Azole antifungals). The voriconazole label: “Drug/Drug Class: Other benzodiazepines including triazolam and alprazolam (CYP3A4 Inhibition); Drug Plasma Exposure (C max and AUC τ): In Vitro Studies Demonstrated Potential for Voriconazole to Inhibit Metabolism; …”
Check it at the source: the alprazolam FDA label on DailyMed (effective January 18, 2023, PHARMACIA & UPJOHN COMPANY LLC); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the alprazolam label say about voriconazole?
Alprazolam's label does not name voriconazole itself; it warns about its class (Azole antifungals):
Alprazolam label, warnings and precautionsStrong CYP3A Inhibitors XANAX is contraindicated in patients receiving strong inhibitors of CYP3A (such as azole antifungal agents), except ritonavir [see Contraindications (4) ].
Source: FDA drug label (Xanax), PHARMACIA & UPJOHN COMPANY LLC, effective January 18, 2023 (SPL set 388e249d-b9b6-44c3-9f8f-880eced0239f), via openFDA; the full label on DailyMed
What does the voriconazole label say about alprazolam?
Voriconazole label, drug interactionsDrug/Drug Class (Mechanism of Interaction by Voriconazole): Other benzodiazepines including triazolam and alprazolam (CYP3A4 Inhibition); Drug Plasma Exposure (C max and AUC τ): In Vitro Studies Demonstrated Potential for Voriconazole to Inhibit Metabolism (Increased Plasma Exposure); Prevention or Management Recommendations: Refer to drug-specific labeling for details.
Voriconazole label (Xellia Pharmaceuticals USA LLC, January 11, 2023), drug interactionsDrug/Drug Class (Mechanism of Interaction by Voriconazole): Other benzodiazepines including triazolam and alprazolam (CYP3A4 Inhibition); Drug Plasma Exposure (C max and AUC τ): In Vitro Studies Demonstrated Potential for Voriconazole to Inhibit Metabolism (Increased Plasma Exposure); Recommendations for Drug Dosage Adjustment/Comments: Refer to drug-specific labeling for details.
Source: FDA drug label (Voriconazole, NDA208562), Xellia Pharmaceuticals USA LLC, effective January 11, 2023 (SPL set 9ec6eda2-2f15-423b-9ec6-819379a426e1), via openFDA
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alprazolam | Voriconazole | |
|---|---|---|
| Labeled for | Anxiety | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0236 per tablet 0.25 mg tablet | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once