Voriconazole and Alprazolam Interaction
Drug interaction information between Voriconazole and Alprazolam.
Voriconazole and Alprazolam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Voriconazole and Alprazolam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Voriconazole slows down how your body processes alprazolam, which may cause the drug to stay in your system longer and increase its effects.
FDA Label Information
Other benzodiazepines including triazolam and alprazolam (CYP3A4 Inhibition) In Vitro Studies Demonstrated Potential for Voriconazole to Inhibit Metabolism (Increased Plasma Exposure) HMG-CoA Reductase Inhibitors (Statins) (CYP3A4 Inhibition) In Vitro Studies Demonstrated Potential for Voriconazole to Inhibit Metabolism (Increased Plasma Exposure) Frequent monitoring for adverse reactions and toxicity related to statins.
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Lurasidone major
- Pimozide major
- Ivabradine major
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Digoxin moderate
- Aprepitant moderate
Frequently Asked Questions
What SPL severity band is on file for Voriconazole + Alprazolam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Voriconazole has 50 labeled pairs on file vs Alprazolam's 27. In the minor band specifically: Voriconazole has 33 (also Omeprazole, Ibuprofen, Oxycodone, Diclofenac); Alprazolam has 20 (also Tramadol, Oxycodone, Morphine, Carbamazepine).
What mechanism field is on file for Voriconazole and Alprazolam?
Voriconazole slows down how your body processes alprazolam, which may cause the drug to stay in your system longer and increase its effects.
Voriconazole carries more major-labeled pairs than Alprazolam
SPL source-record counts only. This page's band is minor · classes on file: Voriconazole (Azole Antifungal); Alprazolam (Benzodiazepine).
Voriconazole has 8 major-labeled pairs vs Alprazolam's 0. This page itself is in the minor band, not the major band.
8 major · 9 moderate · 33 minor · 50 total
- Other minor peers for Voriconazole
- Omeprazole
- Ibuprofen
- Oxycodone
- Diclofenac
0 major · 7 moderate · 20 minor · 27 total
- Other minor peers for Alprazolam
- Tramadol
- Oxycodone
- Morphine
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.