Voriconazole and Ibuprofen Interaction
Drug interaction information between Voriconazole and Ibuprofen.
Voriconazole and Ibuprofen have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Voriconazole and Ibuprofen. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Voriconazole blocks the enzyme that breaks down ibuprofen, which can lead to higher levels of the painkiller in your body.
FDA Label Information
ibuprofen and diclofenac (CYP2C9 Inhibition) Increased Frequent monitoring for adverse reactions and toxicity related to NSAIDs.
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Lurasidone major
- Pimozide major
- Ivabradine major
Ibuprofen Also Interacts With
- Heparin moderate
- Warfarin moderate
- Carbamazepine minor
- Digoxin minor
- Fluconazole minor
Frequently Asked Questions
What SPL severity band is on file for Voriconazole + Ibuprofen?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Voriconazole has 50 labeled pairs on file vs Ibuprofen's 9. In the minor band specifically: Voriconazole has 33 (also Omeprazole, Alprazolam, Oxycodone, Diclofenac); Ibuprofen has 7 (also Carbamazepine, Digoxin, Fluconazole, Prenatal Multivitamin).
What mechanism field is on file for Voriconazole and Ibuprofen?
Voriconazole blocks the enzyme that breaks down ibuprofen, which can lead to higher levels of the painkiller in your body.
Voriconazole carries more major-labeled pairs than Ibuprofen
SPL source-record counts only. This page's band is minor · classes on file: Voriconazole (Azole Antifungal); Ibuprofen (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
Voriconazole has 8 major-labeled pairs vs Ibuprofen's 0. This page itself is in the minor band, not the major band.
8 major · 9 moderate · 33 minor · 50 total
- Other minor peers for Voriconazole
- Omeprazole
- Alprazolam
- Oxycodone
- Diclofenac
0 major · 2 moderate · 7 minor · 9 total
- Other minor peers for Ibuprofen
- Carbamazepine
- Digoxin
- Fluconazole
- Prenatal Multivitamin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.