What the FDA labels say about taking them together
Oxycodone and voriconazole
Voriconazole's FDA label of February 26, 2026 names oxycodone in its drug interactions section; the oxycodone labels PlainMeds reads (4) do not name voriconazole. The voriconazole label: “Oxycodone (CYP3A4 Inhibition) Significantly Increased Increased visual effects (heterophoria and miosis) of oxycodone were observed when concomitantly administered with VFEND.”
Check it at the source: the oxycodone FDA label on DailyMed (effective May 6, 2026, Rhodes Pharmaceuticals LLC); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the oxycodone label say about voriconazole?
Oxycodone's label (effective May 6, 2026) and its 3 other brand-application labels do not name voriconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Oxycodone Hydrochloride), Rhodes Pharmaceuticals LLC, effective May 6, 2026 (SPL set a5162476-1217-41c0-bc7e-0a0f123f069f), via openFDA; the full label on DailyMed
What does the voriconazole label say about oxycodone?
Voriconazole label, drug interactionsOxycodone (CYP3A4 Inhibition) Significantly Increased Increased visual effects (heterophoria and miosis) of oxycodone were observed when concomitantly administered with VFEND.
Source: FDA drug label (Voriconazole, NDA208562), Xellia Pharmaceuticals USA LLC, effective January 11, 2023 (SPL set 9ec6eda2-2f15-423b-9ec6-819379a426e1), via openFDA
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Oxycodone | Voriconazole | |
|---|---|---|
| Labeled for | Pain | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0884 per tablet 5 mg tablet | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once