Triazolam and Aprepitant Interaction
Drug interaction information between Triazolam and Aprepitant.
Triazolam and Aprepitant have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Triazolam and Aprepitant. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Aprepitant slows down the process of clearing triazolam from your body, which can lead to higher levels of the drug in your blood. This makes side effects more likely to happen.
FDA Label Information
Benzodiazepines Clinical Impact Increased exposure to midazolam or other benzodiazepines metabolized via CYP3A4 (alprazolam, triazolam) may increase the risk of adverse reactions [see Clinical Pharmacology ( 12.3 )]. Benzodiazepines Clinical Impact Increased exposure to midazolam or other benzodiazepines metabolized via CYP3A4 (alprazolam, triazolam) may increase the risk of adverse reactions [see Clinical Pharmacology ( 12.3 )].
Triazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Clarithromycin moderate
- Diltiazem minor
Aprepitant Also Interacts With
- Pimozide major
- Alprazolam moderate
- Diltiazem moderate
- Methylprednisolone moderate
- Ketoconazole moderate
Frequently Asked Questions
What SPL severity band is on file for Triazolam + Aprepitant?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aprepitant has 22 labeled pairs on file vs Triazolam's 10. In the moderate band specifically: Triazolam has 2 (also Clarithromycin); Aprepitant has 9 (also Alprazolam, Diltiazem, Methylprednisolone, Ketoconazole).
What mechanism field is on file for Triazolam and Aprepitant?
Aprepitant slows down the process of clearing triazolam from your body, which can lead to higher levels of the drug in your blood. This makes side effects more likely to happen.
Triazolam carries more major-labeled pairs than Aprepitant
SPL source-record counts only. This page's band is moderate · classes on file: Triazolam (Benzodiazepine (Hypnotic)); Aprepitant (NK1 Receptor Antagonist (Antiemetic)).
Triazolam has 3 major-labeled pairs vs Aprepitant's 1. This page itself is in the moderate band, not the major band.
3 major · 2 moderate · 5 minor · 10 total
- Other moderate peers for Triazolam
- Clarithromycin
1 major · 9 moderate · 12 minor · 22 total
- Other moderate peers for Aprepitant
- Alprazolam
- Diltiazem
- Methylprednisolone
- Ketoconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.