Triazolam and Posaconazole Interaction
Drug interaction information between Triazolam and Posaconazole.
Triazolam and Posaconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Triazolam and Posaconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Posaconazole slows down the enzyme that clears triazolam from your system. This can make the effects of the sedative stronger and last longer than intended.
FDA Label Information
Concomitant use of posaconazole and other benzodiazepines metabolized by CYP3A4 (e.g., alprazolam, triazolam) could result in increased plasma concentrations of these benzodiazepines.
Triazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Aprepitant moderate
- Clarithromycin moderate
Posaconazole Also Interacts With
- Esomeprazole major
- Digoxin major
- Cimetidine major
- Metoclopramide major
- Phenytoin major
Frequently Asked Questions
What SPL severity band is on file for Triazolam + Posaconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Posaconazole has 27 labeled pairs on file vs Triazolam's 10. In the minor band specifically: Triazolam has 5 (also Diltiazem, Fluconazole, Tiagabine, Voriconazole); Posaconazole has 17 (also Alprazolam, Glipizide, Diltiazem, Nifedipine).
What mechanism field is on file for Triazolam and Posaconazole?
Posaconazole slows down the enzyme that clears triazolam from your system. This can make the effects of the sedative stronger and last longer than intended.
Posaconazole carries more major-labeled pairs than Triazolam
SPL source-record counts only. This page's band is minor · classes on file: Triazolam (Benzodiazepine (Hypnotic)); Posaconazole (Azole Antifungal).
Posaconazole has 5 major-labeled pairs vs Triazolam's 3. This page itself is in the minor band, not the major band.
3 major · 2 moderate · 5 minor · 10 total
- Other minor peers for Triazolam
- Diltiazem
- Fluconazole
- Tiagabine
- Voriconazole
5 major · 5 moderate · 17 minor · 27 total
- Other minor peers for Posaconazole
- Alprazolam
- Glipizide
- Diltiazem
- Nifedipine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.