Medication class
Mental Health
Medications for depression, anxiety, bipolar disorder, ADHD, and other mental health conditions, including SSRIs, SNRIs, and stimulants.
Data updated 2026-05-15
- 77
- Medications
- 68
- With a generic
- 92%
- Avg generic savings
- 5
- In active shortage
Drug class assignments follow the FDA openFDA therapeutic classification, clinical details are drawn from FDA Structured Product Labeling via DailyMed, and unit-price comparisons use CMS National Average Drug Acquisition Cost data. See the full sources below.
Inventory versus report volume
Mental Health is inventory #1 of 22 (77 drugs) ≠ FAERS-volume #2. Nationally Mental Health is inventory #1 of 22 (77 drugs) ≠ Pain Relief FAERS-volume #1 at inventory #3.
- #1
- inventory
- 77
- tracked drugs
- #2
- FAERS volume
- #1
- Pain Relief FAERS nationally
According to FDA FAERS report totals and openFDA class inventory compiled on /methodology. Class size is not the same map as report volume. This page is for informational purposes only and is not medical advice.
This class - generic availability cut
Exclusive DISTINCT-drug split of 77 medicines in Mental Health. Orthogonal to inventory vs FAERS dual and to the NADAC cost ChartBar.
naltrexone tops Mental Health NADAC at $1579.00/unit
Top 10 acquisition costs in this class (CMS NADAC)
- naltrexone
naltrexone
$1,579 per unit
- esketamine $373
esketamine
$373 per unit
- valbenazine $250
valbenazine
$250 per unit
- diazepam $250
diazepam
$250 per unit
- deutetrabenazine $117
deutetrabenazine
$117 per unit
- selegiline $69
selegiline
$69 per unit
- lurasidone $67
lurasidone
$67 per unit
- brexpiprazole $47
brexpiprazole
$47 per unit
- cariprazine $46
cariprazine
$46 per unit
- rasagiline $37
rasagiline
$37 per unit
What this shows naltrexone is the costliest in this class at $1579.00/unit; generics in the same class run a fraction of that.
Mental Health carries the largest tracked inventory (77 medicines)
21 classes have fewer tracked drugs; percentile 95 among PlainMeds categories.
Mental Health vs all classes by tracked-drug count
Where this class's inventory sits among every PlainMeds therapeutic category
77 1st of 22 the highest of 22 classes
Classes, banded by tracked-drug inventory
Each bar is a band; taller bars hold more classes. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source PlainMeds openFDA therapeutic-class inventory · 2026-05-15
acamprosate
Campral
Acamprosate is a medicine that can help you stay away from alcohol if you are alcohol-dependent and have already stopped drinking.
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alprazolam
Xanax
Alprazolam (Xanax) is a medication that can help you with anxiety and panic disorders.
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amitriptyline
Elavil
Amitriptyline is a medicine used to treat depression.
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amphetamine/dextroamphetamine
Adderall, Adderall XR
Adderall XR is a stimulant medicine.
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aripiprazole
Abilify
Aripiprazole (Abilify) is a medicine used to treat certain mental disorders and mood problems.
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asenapine
Saphris
Asenapine (Saphris) is an antipsychotic medicine.
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atomoxetine
Strattera
Atomoxetine (Strattera) is a medicine that can help people with Attention-Deficit/Hyperactivity Disorder (ADHD).
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brexpiprazole
Rexulti
Rexulti is a medication used to treat certain mental health conditions.
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buprenorphine
Subutex, Sublocade
Buprenorphine sublingual tablets help treat opioid dependence.
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buprenorphine/naloxone
Suboxone
Suboxone film contains buprenorphine and naloxone.
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bupropion
Wellbutrin, Zyban
Bupropion is a medicine used to treat depression and prevent seasonal affective disorder (SAD).
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buspirone
BuSpar
Buspirone is a medicine that can help manage anxiety disorders.
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carbidopa/levodopa
Sinemet
This medicine contains carbidopa, levodopa, and entacapone.
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cariprazine
Vraylar
Vraylar is a medicine used to treat certain mental health conditions.
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chlorpromazine
Thorazine
Chlorpromazine is a medicine that belongs to a class of drugs called phenothiazine antipsychotics.
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citalopram
Celexa
Citalopram is a medicine used to treat depression in adults.
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clomipramine
Anafranil
Clomipramine (Anafranil) is a medicine used to treat obsessive-compulsive disorder (OCD).
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clozapine
Clozaril
Versacloz is a medicine used to treat severe schizophrenia when other medicines have not worked.
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desipramine
Norpramin
Desipramine is a medicine used to treat depression.
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desvenlafaxine
Pristiq
Pristiq is a medicine used to treat depression in adults.
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deutetrabenazine
Austedo
Austedo and Austedo XR help control movements in adults with Huntington's disease or tardive dyskinesia.
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dexmethylphenidate
Focalin, Focalin XR
AZSTARYS is a stimulant medicine used to treat ADHD.
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diazepam
Valium
Diazepam (Valium) is a medicine that can help with anxiety, muscle spasms, and seizures.
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disulfiram
Antabuse
Disulfiram is a medicine that helps people with long-term alcohol problems stay sober.
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donepezil
Aricept
Donepezil is a medicine used to treat dementia caused by Alzheimer's disease.
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doxepin
Sinequan, Silenor
Doxepin is a medicine that can help you stay asleep.
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duloxetine
Cymbalta
Duloxetine is a medicine that can help treat depression and anxiety.
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entacapone
Comtan
Entacapone is a medicine that helps people with Parkinson's disease.
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escitalopram
Lexapro
Escitalopram is a medicine used to treat depression and anxiety.
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esketamine
Spravato
Spravato is a nasal spray medicine used to treat depression.
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fluoxetine
Prozac, Sarafem
Fluoxetine is a medicine that can help treat depression and other mental health conditions.
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fluphenazine
Prolixin
Fluphenazine (Prolixin) is a medicine used to treat psychotic disorders.
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fluvoxamine
Luvox
Fluvoxamine is a medicine that can help treat obsessive compulsive disorder (OCD).
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galantamine
Razadyne
Galantamine extended-release capsules help treat mild to moderate Alzheimer's disease.
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guanfacine
Intuniv, Tenex
Guanfacine extended-release tablets can help treat ADHD.
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haloperidol
Haldol
Haloperidol is a medicine used to treat mental disorders.
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iloperidone
Fanapt
Fanapt is a medicine used to treat schizophrenia and bipolar disorder.
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imipramine
Tofranil
Imipramine (Tofranil) is a medicine used to treat depression and bedwetting in children.
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levomilnacipran
Fetzima
Fetzima is a medicine used to treat major depressive disorder (MDD) in adults.
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lisdexamfetamine
Vyvanse
Lisdexamfetamine (Vyvanse) is a stimulant medicine.
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lithium
Lithobid, Eskalith
Lithium is a mood stabilizer medicine.
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lorazepam
Ativan
Lorazepam is a medicine that can help with anxiety.
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lurasidone
Latuda
Lurasidone (Latuda) is a medicine used to treat schizophrenia and bipolar depression.
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memantine
Namenda
Memantine is a medicine used to treat moderate to severe Alzheimer's disease.
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methadone
Dolophine
Methadone Hydrochloride Injection is a strong pain medicine.
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methylphenidate
Ritalin, Concerta
Methylphenidate extended-release capsules are a stimulant medicine.
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midazolam
Versed
Midazolam is a medicine that makes you feel calm, relaxed, and sleepy.
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mirtazapine
Remeron
Mirtazapine is a medicine used to treat depression in adults.
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naltrexone
Vivitrol, ReVia
Naltrexone is a medicine that can help treat alcohol and opioid dependence.
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nortriptyline
Pamelor
Nortriptyline (Pamelor) is a medicine used to treat depression.
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olanzapine
Zyprexa
Olanzapine is a medicine used to treat certain mental disorders.
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oxcarbazepine
Trileptal
Oxcarbazepine is a medicine used to treat seizures.
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paliperidone
Invega
Paliperidone extended-release tablets, also known as Invega, are a type of antipsychotic medicine.
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paroxetine
Paxil
Paroxetine (Paxil) is a medicine that can help treat depression and anxiety disorders.
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perphenazine
Trilafon
Perphenazine is a medicine used to treat schizophrenia and control severe nausea and vomiting.
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phenelzine
Nardil
Phenelzine (Nardil) is a medicine used to treat depression.
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pimozide
Orap
Pimozide (Orap) is a medicine that helps control tics in people with Tourette's Disorder.
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pramipexole
Mirapex
Pramipexole extended-release tablets help treat Parkinson's disease.
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protriptyline
Vivactil
Protriptyline (Vivactil) is a medicine used to treat depression.
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quetiapine
Seroquel
Quetiapine is a medicine that belongs to a class of drugs called atypical antipsychotics.
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rasagiline
Azilect
Rasagiline (Azilect) is a medicine used to treat Parkinson's disease.
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risperidone
Risperdal
Risperidone is a medicine used to treat certain mental disorders.
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rivastigmine
Exelon
Rivastigmine (Exelon) is a medicine that helps improve memory and thinking in people with dementia.
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ropinirole
Requip
Ropinirole is a medicine that acts like dopamine in your brain.
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safinamide
Xadago
Safinamide (Xadago) is a drug used with levodopa/carbidopa to treat Parkinson's disease.
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selegiline
Emsam
Selegiline is a medicine that can help manage Parkinson's disease.
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sertraline
Zoloft
Sertraline is a medicine used to treat depression and other mental health conditions.
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tetrabenazine
Xenazine
Tetrabenazine is a medicine used to treat chorea (uncontrollable movements) caused by Huntington's disease.
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thioridazine
Mellaril
Thioridazine is a medicine used to treat schizophrenia.
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tranylcypromine
Parnate
Tranylcypromine (Parnate) is a medicine used to treat major depression in adults.
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trazodone
Desyrel
Trazodone is a medicine used to treat depression.
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valbenazine
Ingrezza
Ingrezza and Ingrezza Sprinkle are medicines used to treat movement problems.
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varenicline
Chantix
Varenicline (Chantix) is a medicine that can help you stop smoking.
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venlafaxine
Effexor, Effexor XR
Venlafaxine is a medication used to treat depression.
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vilazodone
Viibryd
Vilazodone (Viibryd) is a medicine used to treat depression in adults.
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vortioxetine
Trintellix
Trintellix is a medicine used to treat major depressive disorder (MDD) in adults.
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ziprasidone
Geodon
Ziprasidone is a medicine used to treat mental disorders.
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Mental Health · large class with 5 active shortages
Mental Health is inventory #1 of 22 (77 drugs) ≠ FAERS-volume #2. Nationally Mental Health is inventory #1 of 22 (77 drugs) ≠ Pain Relief FAERS-volume #1 at inventory #3. 77 medicines tracked; 68 carry a NADAC generic flag; 5 in active FDA shortage.
Classes nearest Mental Health by inventory size
Read our methodology - how this data is sourced, computed, and verified.