Medication class
Acid Reflux & Stomach
Proton pump inhibitors and other drugs that reduce stomach acid to treat GERD, heartburn, and peptic ulcers.
Data updated 2026-05-15
- 38
- Medications
- 30
- With a generic
- 74%
- Avg generic savings
- 1
- In active shortage
Drug class assignments follow the FDA openFDA therapeutic classification, clinical details are drawn from FDA Structured Product Labeling via DailyMed, and unit-price comparisons use CMS National Average Drug Acquisition Cost data. See the full sources below.
Inventory versus report volume
Acid Reflux & Stomach is inventory #8 of 22 (38 drugs) ≠ FAERS-volume #4. Nationally Mental Health is inventory #1 of 22 (77 drugs) ≠ Pain Relief FAERS-volume #1 at inventory #3.
- #8
- inventory
- 38
- tracked drugs
- #4
- FAERS volume
- #1
- Pain Relief FAERS nationally
According to FDA FAERS report totals and openFDA class inventory compiled on /methodology. Class size is not the same map as report volume. This page is for informational purposes only and is not medical advice.
This class - generic availability cut
Exclusive DISTINCT-drug split of 38 medicines in Acid Reflux & Stomach. Orthogonal to inventory vs FAERS dual and to the NADAC cost ChartBar.
aprepitant tops Acid Reflux & Stomach NADAC at $325.00/unit
Top 10 acquisition costs in this class (CMS NADAC)
- aprepitant
aprepitant
$325 per unit
- rifaximin $52
rifaximin
$52 per unit
- eluxadoline $26
eluxadoline
$26 per unit
- plecanatide $18
plecanatide
$18 per unit
- linaclotide $17
linaclotide
$17 per unit
- pantoprazole $14
pantoprazole
$14 per unit
- esomeprazole $7
esomeprazole
$7 per unit
- lubiprostone $6
lubiprostone
$6 per unit
- dexlansoprazole $5
dexlansoprazole
$5 per unit
- sucralfate $5
sucralfate
$5 per unit
What this shows aprepitant is the costliest in this class at $325.00/unit; generics in the same class run a fraction of that.
Acid Reflux & Stomach · #8 inventory of 22 therapeutic classes
14 classes have fewer tracked drugs; percentile 64 among PlainMeds categories.
Acid Reflux & Stomach vs all classes by tracked-drug count
Where this class's inventory sits among every PlainMeds therapeutic category
38 8th of 22 higher than 14 of 22 classes
Classes, banded by tracked-drug inventory
Each bar is a band; taller bars hold more classes. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source PlainMeds openFDA therapeutic-class inventory · 2026-05-15
alosetron
Lotronex
Alosetron (Lotronex) is a medicine for women with severe diarrhea-predominant irritable bowel syndrome (IBS).
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aprepitant
Emend
Aprepitant (Emend) is a medicine that helps prevent nausea and vomiting.
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bisacodyl OTC
Dulcolax
Bisacodyl is a medicine that helps you have a bowel movement.
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bismuth subsalicylate OTC
Pepto-Bismol
Bismuth subsalicylate (Pepto-Bismol) is a medicine that can treat diarrhea and upset stomach.
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cimetidine OTC
Tagamet
Cimetidine (Tagamet) reduces stomach acid.
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dexlansoprazole
Dexilant
Dexlansoprazole (Dexilant) is a medicine that lowers stomach acid.
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dicyclomine
Bentyl
Dicyclomine is a medicine that helps with irritable bowel syndrome.
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diphenoxylate/atropine
Lomotil
Lomotil is a drug that helps manage diarrhea.
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docusate OTC
Colace
Docusate is a stool softener.
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dronabinol
Marinol
Dronabinol capsules contain a synthetic form of THC, the active ingredient in marijuana.
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eluxadoline
Viberzi
Viberzi is a medicine used to treat irritable bowel syndrome with diarrhea (IBS-D) in adults.
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esomeprazole OTC
Nexium
Esomeprazole (Nexium) is a drug that reduces stomach acid.
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famotidine OTC
Pepcid
Famotidine (Pepcid) reduces stomach acid.
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granisetron
Kytril
Granisetron oral solution helps prevent nausea and vomiting caused by cancer treatments like chemotherapy and radiation.
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lactulose
Enulose, Kristalose
Lactulose is a medicine that helps treat and prevent problems with your brain caused by liver disease.
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lansoprazole OTC
Prevacid
Lansoprazole is a medicine that reduces the amount of acid in your stomach.
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linaclotide
Linzess
Linzess is a medicine that helps treat certain bowel problems.
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loperamide OTC
Imodium
Loperamide (Imodium) helps control diarrhea symptoms.
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lubiprostone
Amitiza
Lubiprostone is a medicine that helps treat constipation.
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metoclopramide
Reglan
Metoclopramide is a drug that helps with stomach problems.
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misoprostol
Cytotec
Diclofenac sodium/misoprostol is a combination drug used to treat arthritis symptoms while protecting your stomach from ulcers.
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nabilone
Cesamet
Cesamet contains nabilone, a synthetic cannabinoid.
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nizatidine OTC
Axid
Nizatidine helps reduce stomach acid.
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omeprazole OTC
Prilosec
Omeprazole (Prilosec) is a medicine that reduces the amount of acid in your stomach.
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ondansetron
Zofran
Ondansetron is a medicine that helps prevent nausea and vomiting.
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palonosetron
Aloxi
Palonosetron is a medicine that helps prevent nausea and vomiting.
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pantoprazole
Protonix
Pantoprazole is a drug that reduces stomach acid.
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plecanatide
Trulance
Trulance is a medicine that helps adults with certain bowel problems.
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polyethylene glycol 3350 OTC
MiraLAX
MiraLAX is a laxative medicine.
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prochlorperazine
Compazine
Prochlorperazine is a medicine that can help control severe nausea and vomiting.
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promethazine
Phenergan
Promethazine suppositories are a medicine that can help with allergies, motion sickness, nausea, vomiting, and sleep problems.
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psyllium OTC
Metamucil
Metamucil is a fiber supplement that helps you have regular bowel movements.
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rabeprazole
Aciphex
Rabeprazole (Aciphex) is a medicine that reduces the amount of acid your stomach makes.
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ranitidine OTC
Zantac
Ranitidine (Zantac) helps reduce stomach acid.
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rifaximin
Xifaxan
Xifaxan is an antibiotic medicine.
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rolapitant
Varubi
Varubi is a medicine that helps prevent nausea and vomiting caused by chemotherapy.
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senna OTC
Senokot
Senna (Senokot) is a stimulant laxative.
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sucralfate
Carafate
Sucralfate is a medicine that helps heal and protect ulcers in your small intestine.
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Acid Reflux & Stomach · large class with 1 active shortage
Acid Reflux & Stomach is inventory #8 of 22 (38 drugs) ≠ FAERS-volume #4. Nationally Mental Health is inventory #1 of 22 (77 drugs) ≠ Pain Relief FAERS-volume #1 at inventory #3. 38 medicines tracked; 30 carry a NADAC generic flag; 1 in active FDA shortage.
Classes nearest Acid Reflux & Stomach by inventory size
Read our methodology - how this data is sourced, computed, and verified.