Medication class
Acid Reflux & Stomach
Proton pump inhibitors and other drugs that reduce stomach acid to treat GERD, heartburn, and peptic ulcers.
Data updated 2026-05-15
- 38
- Medications
- 30
- With a generic
- 74%
- Avg generic savings
- 1
- In active shortage
Drug class assignments follow the FDA openFDA therapeutic classification, and clinical details are drawn from FDA Structured Product Labeling (DailyMed). See the full sources below.
PlainMeds tracks 38 acid reflux & stomach medications compiled from official FDA drug labels, including omeprazole, pantoprazole, ranitidine.
Acid Reflux & Stomach medications are grouped here by the openFDA therapeutic classification and drawn from FDA Structured Product Labeling. PlainMeds lists 38 in this class, 30 with a lower-cost generic available (averaging about 74% versus brand). Each drug page covers labeled uses, FAERS-reported side effects, interactions, recalls and NADAC pricing. This is educational information from public data, not medical advice.
What acid reflux & stomach drugs cost
Highest NADAC acquisition cost per unit in this class, brand and generic
- aprepitant
aprepitant
$325 per unit
- rifaximin $52
rifaximin
$52 per unit
- eluxadoline $26
eluxadoline
$26 per unit
- plecanatide $18
plecanatide
$18 per unit
- linaclotide $17
linaclotide
$17 per unit
- pantoprazole $14
pantoprazole
$14 per unit
- esomeprazole $7
esomeprazole
$7 per unit
- lubiprostone $6
lubiprostone
$6 per unit
- dexlansoprazole $5
dexlansoprazole
$5 per unit
- sucralfate $5
sucralfate
$5 per unit
What this shows aprepitant is the costliest in this class at $325.00/unit; generics in the same class run a fraction of that.
Generic availability vs other classes
79% of acid reflux & stomach medications have a generic available, ranking #9 of 22 therapeutic classes (the typical class sits near 74%).
Source: CMS NADAC generic-availability flags across all PlainMeds therapeutic classes. The dot is this class; the line is the cross-class median.
alosetron
Lotronex
Alosetron (Lotronex) is a medicine for women with severe diarrhea-predominant irritable bowel syndrome (IBS).
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aprepitant
Emend
Aprepitant (Emend) is a medicine that helps prevent nausea and vomiting.
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bisacodyl OTC
Dulcolax
Bisacodyl is a medicine that helps you have a bowel movement.
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bismuth subsalicylate OTC
Pepto-Bismol
Bismuth subsalicylate (Pepto-Bismol) is a medicine that can treat diarrhea and upset stomach.
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cimetidine OTC
Tagamet
Cimetidine (Tagamet) reduces stomach acid.
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dexlansoprazole
Dexilant
Dexlansoprazole (Dexilant) is a medicine that lowers stomach acid.
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dicyclomine
Bentyl
Dicyclomine is a medicine that helps with irritable bowel syndrome.
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diphenoxylate/atropine
Lomotil
Lomotil is a drug that helps manage diarrhea.
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docusate OTC
Colace
Docusate is a stool softener.
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dronabinol
Marinol
Dronabinol capsules contain a synthetic form of THC, the active ingredient in marijuana.
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eluxadoline
Viberzi
Viberzi is a medicine used to treat irritable bowel syndrome with diarrhea (IBS-D) in adults.
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esomeprazole OTC
Nexium
Esomeprazole (Nexium) is a drug that reduces stomach acid.
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famotidine OTC
Pepcid
Famotidine (Pepcid) reduces stomach acid.
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granisetron
Kytril
Granisetron oral solution helps prevent nausea and vomiting caused by cancer treatments like chemotherapy and radiation.
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lactulose
Enulose, Kristalose
Lactulose is a medicine that helps treat and prevent problems with your brain caused by liver disease.
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lansoprazole OTC
Prevacid
Lansoprazole is a medicine that reduces the amount of acid in your stomach.
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linaclotide
Linzess
Linzess is a medicine that helps treat certain bowel problems.
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loperamide OTC
Imodium
Loperamide (Imodium) helps control diarrhea symptoms.
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lubiprostone
Amitiza
Lubiprostone is a medicine that helps treat constipation.
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metoclopramide
Reglan
Metoclopramide is a drug that helps with stomach problems.
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misoprostol
Cytotec
Diclofenac sodium/misoprostol is a combination drug used to treat arthritis symptoms while protecting your stomach from ulcers.
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nabilone
Cesamet
Cesamet contains nabilone, a synthetic cannabinoid.
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nizatidine OTC
Axid
Nizatidine helps reduce stomach acid.
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omeprazole OTC
Prilosec
Omeprazole (Prilosec) is a medicine that reduces the amount of acid in your stomach.
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ondansetron
Zofran
Ondansetron is a medicine that helps prevent nausea and vomiting.
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palonosetron
Aloxi
Palonosetron is a medicine that helps prevent nausea and vomiting.
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pantoprazole
Protonix
Pantoprazole is a drug that reduces stomach acid.
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plecanatide
Trulance
Trulance is a medicine that helps adults with certain bowel problems.
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polyethylene glycol 3350 OTC
MiraLAX
MiraLAX is a laxative medicine.
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prochlorperazine
Compazine
Prochlorperazine is a medicine that can help control severe nausea and vomiting.
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promethazine
Phenergan
Promethazine suppositories are a medicine that can help with allergies, motion sickness, nausea, vomiting, and sleep problems.
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psyllium OTC
Metamucil
Metamucil is a fiber supplement that helps you have regular bowel movements.
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rabeprazole
Aciphex
Rabeprazole (Aciphex) is a medicine that reduces the amount of acid your stomach makes.
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ranitidine OTC
Zantac
Ranitidine (Zantac) helps reduce stomach acid.
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rifaximin
Xifaxan
Xifaxan is an antibiotic medicine.
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rolapitant
Varubi
Varubi is a medicine that helps prevent nausea and vomiting caused by chemotherapy.
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senna OTC
Senokot
Senna (Senokot) is a stimulant laxative.
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sucralfate
Carafate
Sucralfate is a medicine that helps heal and protect ulcers in your small intestine.
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Understanding the Acid Reflux & Stomach Category
The Acid Reflux & Stomach category currently lists 38 medications in this database, each drawn from FDA drug labels and grouped by therapeutic classification. Proton pump inhibitors and other drugs that reduce stomach acid to treat GERD, heartburn, and peptic ulcers. Clinical guidelines usually treat these medications as a reference set when weighing treatment options, switching strategies, or comparing safety profiles.
Within this category you'll find examples such as omeprazole, pantoprazole, ranitidine, alongside 35 other entries. Each drug page links to the same underlying FDA data, labeled uses, adverse events reported to FAERS, documented interactions, warnings, and, where available, NADAC acquisition pricing from CMS. Over-the-counter and prescription options can sit in the same category but follow different regulatory pathways: OTC products have simplified labeling aimed at self-care, while prescription drugs include detailed monographs meant for clinicians. That distinction matters when comparing dosing, monitoring requirements, and contraindications.
Browsing a category is a research starting point, not a treatment recommendation. Effectiveness, tolerability, and cost for any individual patient depend on the specific condition, comorbidities, other medications, genetics, and insurance coverage, none of which can be inferred from a category list alone. FAERS report counts, recall history, and shortage status all evolve as new data is reported to the FDA, so the relative standing of drugs in this class can shift month to month. This page is for educational purposes only and is not medical advice, a licensed clinician is the right source for personalized guidance.
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Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.