Medication class
Pain Relief
Over-the-counter and prescription pain medications, including NSAIDs, acetaminophen, and opioid analgesics for acute and chronic pain.
Data updated 2026-05-15
- 55
- Medications
- 41
- With a generic
- 89%
- Avg generic savings
- 8
- In active shortage
Drug class assignments follow the FDA openFDA therapeutic classification, clinical details are drawn from FDA Structured Product Labeling via DailyMed, and unit-price comparisons use CMS National Average Drug Acquisition Cost data. See the full sources below.
Inventory versus report volume
Pain Relief is inventory #3 of 22 (55 drugs) ≠ FAERS-volume #1. Nationally Mental Health is inventory #1 of 22 (77 drugs) ≠ Pain Relief FAERS-volume #1 at inventory #3.
- #3
- inventory
- 55
- tracked drugs
- #1
- FAERS volume
- #1
- Pain Relief FAERS nationally
According to FDA FAERS report totals and openFDA class inventory compiled on /methodology. Class size is not the same map as report volume. This page is for informational purposes only and is not medical advice.
This class - generic availability cut
Exclusive DISTINCT-drug split of 55 medicines in Pain Relief. Orthogonal to inventory vs FAERS dual and to the NADAC cost ChartBar.
secukinumab tops Pain Relief NADAC at $7207.00/unit
Top 10 acquisition costs in this class (CMS NADAC)
- secukinumab
secukinumab
$7,207 per unit
- golimumab
golimumab
$6,819 per unit
- certolizumab
certolizumab
$5,525 per unit
- adalimumab
adalimumab
$3,361 per unit
- etanercept $1,854
etanercept
$1,854 per unit
- sarilumab $1,853
sarilumab
$1,853 per unit
- abatacept $1,383
abatacept
$1,383 per unit
- infliximab $1,136
infliximab
$1,136 per unit
- methotrexate $471
methotrexate
$471 per unit
- tofacitinib $94
tofacitinib
$94 per unit
What this shows secukinumab is the costliest in this class at $7207.00/unit; generics in the same class run a fraction of that.
Pain Relief · #3 inventory of 22 therapeutic classes
19 classes have fewer tracked drugs; percentile 86 among PlainMeds categories.
Pain Relief vs all classes by tracked-drug count
Where this class's inventory sits among every PlainMeds therapeutic category
55 3rd of 22 higher than 19 of 22 classes
Classes, banded by tracked-drug inventory
Each bar is a band; taller bars hold more classes. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source PlainMeds openFDA therapeutic-class inventory · 2026-05-15
abatacept
Orencia
Orencia is a medicine that helps to reduce inflammation.
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acetaminophen OTC
Tylenol
Acetaminophen (Tylenol) is a medicine that can relieve pain and reduce fever.
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acetaminophen/hydrocodone
Vicodin, Norco, Lortab
This medicine contains acetaminophen and hydrocodone.
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acetaminophen/oxycodone
Percocet
Percocet is a strong pain medicine.
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adalimumab
Humira
Idacio is a medicine that blocks a protein called TNF.
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allopurinol
Zyloprim
Allopurinol is a medicine that lowers uric acid levels in your body.
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baricitinib
Olumiant
Olumiant contains baricitinib.
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buprenorphine (pain)
Belbuca, Butrans
Belbuca is a medicine used to treat severe, long-lasting pain.
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butorphanol
Stadol
Butorphanol nasal spray is a strong pain medicine.
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capsaicin OTC
Zostrix, Qutenza
Capsaicin cream is a medicine that helps relieve minor aches and pains.
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celecoxib
Celebrex
Celecoxib (Celebrex) is a medicine that reduces pain and swelling.
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certolizumab
Cimzia
Cimzia is a medicine that blocks a protein called TNF.
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codeine
Codeine Sulfate
This medicine contains acetaminophen and codeine.
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colchicine
Colcrys, Mitigare
Colchicine is a medicine used to prevent or treat gout flares and Familial Mediterranean Fever (FMF).
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diclofenac OTC
Voltaren, Cataflam
Diclofenac is a gel that helps with arthritis pain in your hands, wrists, elbows, feet, ankles, or knees.
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diclofenac topical OTC
Voltaren Gel, Pennsaid
Diclofenac topical gel is a medicine that helps relieve arthritis pain.
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diflunisal
Dolobid
Diflunisal is a medicine that can help with pain and swelling.
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etanercept
Enbrel
Enbrel is a medicine that blocks a protein called tumor necrosis factor (TNF).
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etodolac
Lodine
Etodolac is a pain reliever and anti-inflammatory medicine.
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febuxostat
Uloric
Febuxostat (Uloric) helps manage high uric acid levels in adults with gout.
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fentanyl
Duragesic, Actiq
Fentanyl Citrate Injection is a strong opioid pain medicine.
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golimumab
Simponi
Simponi Aria is a medicine that blocks a protein called TNF.
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hydromorphone
Dilaudid
Hydromorphone (Dilaudid) is a strong pain medicine.
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hydroxychloroquine
Plaquenil
Hydroxychloroquine is a drug used to treat or prevent malaria, and to treat certain autoimmune diseases.
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ibuprofen OTC
Advil, Motrin
Ibuprofen is a drug that can reduce pain and fever.
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indomethacin
Indocin
Indomethacin is a drug that reduces pain and swelling.
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infliximab
Remicade
Inflectra is a medicine that blocks a protein called TNF.
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ketoprofen
Orudis
Ketoprofen extended-release capsules are a type of NSAID medicine.
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ketorolac
Toradol
Ketorolac (Toradol) is a strong pain reliever.
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leflunomide
Arava
Leflunomide is a drug that can help reduce the symptoms of rheumatoid arthritis.
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lidocaine topical
Lidoderm
Lidoderm is a skin patch that contains the numbing medicine lidocaine.
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mefenamic acid
Ponstel
Mefenamic acid is a medicine used to treat mild to moderate pain and menstrual cramps.
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meloxicam
Mobic
Meloxicam is a non-steroidal anti-inflammatory drug (NSAID).
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meperidine
Demerol
Meperidine is a strong pain medicine.
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methotrexate
Trexall, Otrexup
Methotrexate is a drug that can treat certain cancers, rheumatoid arthritis, psoriasis, and other conditions.
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methylprednisolone
Medrol
Methylprednisolone (Medrol) is a corticosteroid medicine.
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morphine
MS Contin, Kadian
Morphine is a strong pain medicine.
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nabumetone
Relafen
Nabumetone is a medicine that helps reduce pain and swelling.
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nalbuphine
Nubain
Nalbuphine injection is a strong pain medicine.
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naproxen OTC
Aleve, Naprosyn
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID).
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oxaprozin
Daypro
Oxaprozin (Daypro) is a nonsteroidal anti-inflammatory drug (NSAID).
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oxycodone
OxyContin, Roxicodone
Oxycodone is a strong pain medicine.
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pegloticase
Krystexxa
Krystexxa is a medicine used to treat chronic gout in adults when other treatments don't work well enough.
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piroxicam
Feldene
Piroxicam is a medicine that reduces pain and swelling.
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prednisone
Deltasone, Rayos
Prednisone is a steroid medicine that reduces inflammation in the body.
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probenecid
Benemid
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sarilumab
Kevzara
Kevzara is a medicine that can help treat rheumatoid arthritis, polymyalgia rheumatica and polyarticular juvenile idiopathic arthritis.
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secukinumab
Cosentyx
Cosentyx is a medicine that can help reduce inflammation in your body.
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sulfasalazine
Azulfidine
Sulfasalazine is a drug that reduces inflammation in the body.
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sulindac
Clinoril
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID).
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sumatriptan
Imitrex
Sumatriptan injection is a medicine used to treat migraine and cluster headaches.
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tapentadol
Nucynta
Nucynta is a strong pain medicine.
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tofacitinib
Xeljanz
Xeljanz is a medicine that reduces inflammation in your body.
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tramadol
Ultram, ConZip
Tramadol extended-release is a strong pain medicine.
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upadacitinib
Rinvoq
Rinvoq contains upadacitinib and it is a medicine that reduces inflammation in your body.
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Pain Relief · large class with 8 active shortages
Pain Relief is inventory #3 of 22 (55 drugs) ≠ FAERS-volume #1. Nationally Mental Health is inventory #1 of 22 (77 drugs) ≠ Pain Relief FAERS-volume #1 at inventory #3. 55 medicines tracked; 41 carry a NADAC generic flag; 8 in active FDA shortage.
Classes nearest Pain Relief by inventory size
Read our methodology - how this data is sourced, computed, and verified.