Medication class

Pain Relief

Over-the-counter and prescription pain medications, including NSAIDs, acetaminophen, and opioid analgesics for acute and chronic pain.

Data updated 2026-05-15

55
Medications
41
With a generic
89%
Avg generic savings
8
In active shortage

Drug class assignments follow the FDA openFDA therapeutic classification, clinical details are drawn from FDA Structured Product Labeling via DailyMed, and unit-price comparisons use CMS National Average Drug Acquisition Cost data. See the full sources below.

Inventory versus report volume

Pain Relief is inventory #3 of 22 (55 drugs) ≠ FAERS-volume #1. Nationally Mental Health is inventory #1 of 22 (77 drugs) ≠ Pain Relief FAERS-volume #1 at inventory #3.

#3
inventory
55
tracked drugs
#1
FAERS volume
#1
Pain Relief FAERS nationally

According to FDA FAERS report totals and openFDA class inventory compiled on /methodology. Class size is not the same map as report volume. This page is for informational purposes only and is not medical advice.

This class - generic availability cut

Exclusive DISTINCT-drug split of 55 medicines in Pain Relief. Orthogonal to inventory vs FAERS dual and to the NADAC cost ChartBar.

secukinumab tops Pain Relief NADAC at $7207.00/unit

Top 10 acquisition costs in this class (CMS NADAC)

per unit

What this shows secukinumab is the costliest in this class at $7207.00/unit; generics in the same class run a fraction of that.

Source CMS National Average Drug Acquisition Cost (NADAC)

Pain Relief · #3 inventory of 22 therapeutic classes

19 classes have fewer tracked drugs; percentile 86 among PlainMeds categories.

Pain Relief vs all classes by tracked-drug count

Where this class's inventory sits among every PlainMeds therapeutic category

55 3rd of 22 higher than 19 of 22 classes

Classes, banded by tracked-drug inventory

Each bar is a band; taller bars hold more classes. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source PlainMeds openFDA therapeutic-class inventory · 2026-05-15

abatacept

Orencia

Orencia is a medicine that helps to reduce inflammation.

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acetaminophen OTC

Tylenol

Acetaminophen (Tylenol) is a medicine that can relieve pain and reduce fever.

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acetaminophen/hydrocodone

Vicodin, Norco, Lortab

This medicine contains acetaminophen and hydrocodone.

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acetaminophen/oxycodone

Percocet

Percocet is a strong pain medicine.

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adalimumab

Humira

Idacio is a medicine that blocks a protein called TNF.

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allopurinol

Zyloprim

Allopurinol is a medicine that lowers uric acid levels in your body.

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baricitinib

Olumiant

Olumiant contains baricitinib.

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buprenorphine (pain)

Belbuca, Butrans

Belbuca is a medicine used to treat severe, long-lasting pain.

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butorphanol

Stadol

Butorphanol nasal spray is a strong pain medicine.

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capsaicin OTC

Zostrix, Qutenza

Capsaicin cream is a medicine that helps relieve minor aches and pains.

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celecoxib

Celebrex

Celecoxib (Celebrex) is a medicine that reduces pain and swelling.

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certolizumab

Cimzia

Cimzia is a medicine that blocks a protein called TNF.

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codeine

Codeine Sulfate

This medicine contains acetaminophen and codeine.

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colchicine

Colcrys, Mitigare

Colchicine is a medicine used to prevent or treat gout flares and Familial Mediterranean Fever (FMF).

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diclofenac OTC

Voltaren, Cataflam

Diclofenac is a gel that helps with arthritis pain in your hands, wrists, elbows, feet, ankles, or knees.

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diclofenac topical OTC

Voltaren Gel, Pennsaid

Diclofenac topical gel is a medicine that helps relieve arthritis pain.

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diflunisal

Dolobid

Diflunisal is a medicine that can help with pain and swelling.

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etanercept

Enbrel

Enbrel is a medicine that blocks a protein called tumor necrosis factor (TNF).

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etodolac

Lodine

Etodolac is a pain reliever and anti-inflammatory medicine.

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febuxostat

Uloric

Febuxostat (Uloric) helps manage high uric acid levels in adults with gout.

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fentanyl

Duragesic, Actiq

Fentanyl Citrate Injection is a strong opioid pain medicine.

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golimumab

Simponi

Simponi Aria is a medicine that blocks a protein called TNF.

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hydromorphone

Dilaudid

Hydromorphone (Dilaudid) is a strong pain medicine.

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hydroxychloroquine

Plaquenil

Hydroxychloroquine is a drug used to treat or prevent malaria, and to treat certain autoimmune diseases.

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ibuprofen OTC

Advil, Motrin

Ibuprofen is a drug that can reduce pain and fever.

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indomethacin

Indocin

Indomethacin is a drug that reduces pain and swelling.

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infliximab

Remicade

Inflectra is a medicine that blocks a protein called TNF.

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ketoprofen

Orudis

Ketoprofen extended-release capsules are a type of NSAID medicine.

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ketorolac

Toradol

Ketorolac (Toradol) is a strong pain reliever.

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leflunomide

Arava

Leflunomide is a drug that can help reduce the symptoms of rheumatoid arthritis.

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lidocaine topical

Lidoderm

Lidoderm is a skin patch that contains the numbing medicine lidocaine.

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mefenamic acid

Ponstel

Mefenamic acid is a medicine used to treat mild to moderate pain and menstrual cramps.

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meloxicam

Mobic

Meloxicam is a non-steroidal anti-inflammatory drug (NSAID).

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meperidine

Demerol

Meperidine is a strong pain medicine.

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methotrexate

Trexall, Otrexup

Methotrexate is a drug that can treat certain cancers, rheumatoid arthritis, psoriasis, and other conditions.

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methylprednisolone

Medrol

Methylprednisolone (Medrol) is a corticosteroid medicine.

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morphine

MS Contin, Kadian

Morphine is a strong pain medicine.

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nabumetone

Relafen

Nabumetone is a medicine that helps reduce pain and swelling.

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nalbuphine

Nubain

Nalbuphine injection is a strong pain medicine.

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naproxen OTC

Aleve, Naprosyn

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID).

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oxaprozin

Daypro

Oxaprozin (Daypro) is a nonsteroidal anti-inflammatory drug (NSAID).

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oxycodone

OxyContin, Roxicodone

Oxycodone is a strong pain medicine.

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pegloticase

Krystexxa

Krystexxa is a medicine used to treat chronic gout in adults when other treatments don't work well enough.

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piroxicam

Feldene

Piroxicam is a medicine that reduces pain and swelling.

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prednisone

Deltasone, Rayos

Prednisone is a steroid medicine that reduces inflammation in the body.

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probenecid

Benemid

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sarilumab

Kevzara

Kevzara is a medicine that can help treat rheumatoid arthritis, polymyalgia rheumatica and polyarticular juvenile idiopathic arthritis.

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secukinumab

Cosentyx

Cosentyx is a medicine that can help reduce inflammation in your body.

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sulfasalazine

Azulfidine

Sulfasalazine is a drug that reduces inflammation in the body.

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sulindac

Clinoril

Sulindac is a nonsteroidal anti-inflammatory drug (NSAID).

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sumatriptan

Imitrex

Sumatriptan injection is a medicine used to treat migraine and cluster headaches.

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tapentadol

Nucynta

Nucynta is a strong pain medicine.

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tofacitinib

Xeljanz

Xeljanz is a medicine that reduces inflammation in your body.

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tramadol

Ultram, ConZip

Tramadol extended-release is a strong pain medicine.

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upadacitinib

Rinvoq

Rinvoq contains upadacitinib and it is a medicine that reduces inflammation in your body.

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Compare abatacept vs acetaminophen side-by-side →

Pain Relief · large class with 8 active shortages

Pain Relief is inventory #3 of 22 (55 drugs) ≠ FAERS-volume #1. Nationally Mental Health is inventory #1 of 22 (77 drugs) ≠ Pain Relief FAERS-volume #1 at inventory #3. 55 medicines tracked; 41 carry a NADAC generic flag; 8 in active FDA shortage.

Classes nearest Pain Relief by inventory size