Prescription medication · Atypical Antipsychotic
iloperidone
Also sold as Fanapt. Fanapt is used to treat schizophrenia in adults.
Data updated 2026-05-15
- 1,388
- FDA reportsRarely reported
- 5
- InteractionsFew interactions
- $28.54
- Brand price (NADAC)
What the data shows
iloperidone (Fanapt) is a prescription Atypical Antipsychotic, among the least-reported drugs the FDA tracks (1,388 FDA reports), with 5 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
iloperidone (Fanapt) is a prescription Atypical Antipsychotic. Fanapt is used to treat schizophrenia in adults.
Fanapt is a medicine used to treat schizophrenia and bipolar disorder. It helps to balance chemicals in the brain to improve mood and behavior.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Brand Price
$28.54/unit
Generic Available
Yes (1 manufacturer)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Fanapt is used to treat schizophrenia in adults.
Common side effects
Dizziness, Dry mouth, Feeling tired
Key warnings
Fanapt may increase the risk of death in elderly patients who have psychosis related to dementia.
The sections below are summarized in plain English from iloperidone's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Fanapt is an atypical antipsychotic. It works by affecting certain chemicals in the brain, such as dopamine and serotonin. This helps to reduce symptoms of schizophrenia and bipolar disorder.
How to Take It
Take Fanapt twice a day, with or without food. Your doctor will likely start you on a low dose and slowly increase it. This helps to avoid low blood pressure when standing up. Follow your doctor's instructions carefully.
This is a plain-language summary of iloperidone's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.
Pregnancy & Breastfeeding
Tell your doctor if you are pregnant or plan to become pregnant. Babies born to mothers who take antipsychotics like Fanapt in the last 3 months of pregnancy may have withdrawal symptoms after birth. Talk to your doctor about whether to breastfeed while taking Fanapt.
This is a plain-language summary of iloperidone's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is close to your next dose, skip the missed dose and continue with your regular schedule.
This is a plain-language summary of iloperidone's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.
Storage
Store Fanapt tablets at room temperature, away from light and moisture.
Side Effects (from patient reports)
Based on 1,388 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for iloperidone, by number of reports
- Feeling lightheaded or unsteady
Feeling lightheaded or unsteady
99 reports
- Trouble sleeping
Trouble sleeping
83 reports
- Gaining weight
Gaining weight
76 reports
- Feeling worried or nervous
Feeling worried or nervous
68 reports
- Feeling tired
Feeling tired
66 reports
- Uncontrolled muscle movements
Uncontrolled muscle movements
51 reports
- Feeling sick to your stomach
Feeling sick to your stomach
50 reports
- Thoughts of harming yourself
Thoughts of harming yourself
48 reports
- Difficulty breathing
Difficulty breathing
47 reports
- Feeling sleepy
Feeling sleepy
47 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for iloperidone each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where iloperidone sits
iloperidone has more FDA adverse-event reports than 9% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is iloperidone; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 1,388 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2009–2025.
Total Reports
1,388
Reports Mentioning Death
59
4.3% of reports — not proof of cause
Hospitalization Reports
216
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 2 | DIZZINESS | 99 |
| 3 | INSOMNIA | 83 |
| 4 | WEIGHT INCREASED | 76 |
| 5 | ANXIETY | 68 |
| 6 | FATIGUE | 66 |
| 7 | DYSKINESIA | 51 |
| 8 | NAUSEA | 50 |
| 9 | SUICIDAL IDEATION | 48 |
| 10 | DYSPNOEA | 47 |
| 11 | SOMNOLENCE | 47 |
| 12 | AGGRESSION | 45 |
| 14 | SPEECH DISORDER | 40 |
| 15 | VOMITING | 40 |
| 16 | FALL | 38 |
| 17 | TACHYCARDIA | 38 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Fanapt may increase the risk of death in elderly patients who have psychosis related to dementia. Fanapt is not approved to treat this condition.
Known Drug Interactions
Coadministration of paroxetine with iloperidone resulted in increased mean steady-state peak concentrations of iloperidone and its metabolite P88, by about 1.6- fold, and decreased mean steady-state peak concentrations of its metabolite P95 by one-half [see Clinical Pharmacology (12.3 , 12.5) ] . Concomitant use of Strong CYP2D6 and Strong CYP3A4 Inhibitors Clinical Impact Coadministration of iloperidone with paroxetine and ketoconazole resulted in a 1.4- fold increase in steady-state concentrations of iloperidone and its metabolite P88 and a 1.4- fold decrease in the P95 in the presence...
Mechanism: Paroxetine blocks a liver protein that usually breaks down iloperidone, which causes the drug to stay in your body longer.
What to do: Your doctor may need to reduce your dose of iloperidone to prevent side effects.
Strong CYP3A4 Inhibitors Clinical Impact Co-administration of ketoconazole with iloperidone, increased the AUC of iloperidone and its metabolites P88 and P95 by 57%, 55%, and 35%, respectively [see Clinical Pharmacology (12.3) ] . Concomitant use of Strong CYP2D6 and Strong CYP3A4 Inhibitors Clinical Impact Coadministration of iloperidone with paroxetine and ketoconazole resulted in a 1.4- fold increase in steady-state concentrations of iloperidone and its metabolite P88 and a 1.4- fold decrease in the P95 in the presence of paroxetine [see Clinical Pharmacology (12.3) ] .
Mechanism: Ketoconazole stops a liver enzyme from clearing iloperidone, which increases the amount of medicine in your bloodstream.
What to do: Your doctor may need to adjust your iloperidone dose and monitor you for side effects.
Drugs that cause QT prolongation include: specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, thioridazine, mesoridazine, droperidol, and pimozide), specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin), Class 1A antiarrhythmics (e.g., quinidine, procainamide) or Class III antiarrhythmics (e.g., amiodarone, sotalol), and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus) [see Warnings and Precautions (5.9) ] .
Mechanism: Taking these two drugs together can increase the risk of heart rhythm problems because both affect the heart's electrical timing.
What to do: Your healthcare provider should monitor your heart rhythm closely and may need to adjust your treatment plan.
These include: specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol); specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin); Class 1A antiarrhythmic medications (e.g., quinidine, procainamide); Class III antiarrhythmics (e.g., amiodarone, sotalol); and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus).
Mechanism: Both of these drugs can change the way your heart beats, which may lead to serious heart rhythm problems.
What to do: Talk to your doctor about having your heart rhythm checked regularly while taking these medications.
aripiprazole, brexpiprazole, cariprazine, iloperidone, lumateperone, pimavanserin ↑ aripiprazole ↑ brexpiprazole ↑ cariprazine ↑ iloperidone ↑ lumateperone ↑ pimavanserin Dosage adjustment of aripiprazole, brexpiprazole, cariprazine, iloperidone, lumateperone, and pimavanserin is recommended.
Mechanism: Ritonavir slows down the process your body uses to remove iloperidone, which increases the amount of medicine in your blood.
What to do: A dose change for iloperidone is recommended to keep the drug at a safe level in your body.
This is a plain-language summary of interactions documented in FDA labeling, not individualized advice. Ask a pharmacist or prescriber before combining medications.
Common Questions
Can I take Fanapt with food?
What should I do if I feel dizzy after taking Fanapt?
How long will it take for Fanapt to start working?
Can I stop taking Fanapt suddenly?
Will Fanapt make me gain weight?
Can I drink alcohol while taking Fanapt?
What if I have trouble swallowing the pill?
Does Fanapt interact with other medications?
Can Fanapt cause diabetes?
What do I do if I have muscle stiffness or tremors?
What are the common side effects of iloperidone?
Does iloperidone interact with other medications?
What drug class is iloperidone?
Is iloperidone safe during pregnancy?
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Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
Why some drugs demand precise dosing and monitoring
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for iloperidone
The FDA label for iloperidone (sold under brand names such as Fanapt) classifies it as a prescription-only medication in the Atypical Antipsychotic class. Fanapt is used to treat schizophrenia in adults. Official labeling lists 8 commonly reported side effects, including Dizziness, Dry mouth, Feeling tired.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 1,388 voluntary reports. The database also lists 5 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated minor severity. NADAC pricing from CMS.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice, always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: June 30, 2025
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages