Prescription medication · Atypical Antipsychotic
iloperidone
Also sold as Fanapt. Fanapt is used to treat schizophrenia in adults.
Data updated 2026-05-15
- 1,388
- FDA reportsRarely reported
- 5
- InteractionsFew interactions
- $28.54
- Brand price (NADAC)
What the data shows
iloperidone (Fanapt) is a prescription Atypical Antipsychotic, among the least-reported drugs the FDA tracks (1,388 FDA reports), with 5 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
iloperidone (Fanapt) is a prescription Atypical Antipsychotic. Fanapt is used to treat schizophrenia in adults.
Fanapt is a medicine used to treat schizophrenia and bipolar disorder. It helps to balance chemicals in the brain to improve mood and behavior.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Brand Price
$28.54/unit
Generic Available
Yes (1 manufacturer)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Fanapt is used to treat schizophrenia in adults.
Common side effects
Dizziness, Dry mouth, Feeling tired
Key warnings
Fanapt may increase the risk of death in elderly patients who have psychosis related to dementia.
The sections below are summarized in plain English from iloperidone's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Fanapt is an atypical antipsychotic. It works by affecting certain chemicals in the brain, such as dopamine and serotonin. This helps to reduce symptoms of schizophrenia and bipolar disorder.
Side Effects (from patient reports)
Based on 1,388 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for iloperidone, by number of reports
- Dizziness
Dizziness
99 reports
- Insomnia
Insomnia
83 reports
- Weight Increased
Weight Increased
76 reports
- Anxiety
Anxiety
68 reports
- Fatigue
Fatigue
66 reports
- Dyskinesia
Dyskinesia
51 reports
- Nausea
Nausea
50 reports
- Suicidal Ideation
Suicidal Ideation
48 reports
- Dyspnoea
Dyspnoea
47 reports
- Somnolence
Somnolence
47 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for iloperidone each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where iloperidone sits
iloperidone has more FDA adverse-event reports than 9% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is iloperidone; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 1,388 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2009–2025.
Total Reports
1,388
Reports Mentioning Death
59
4.3% of reports — not proof of cause
Hospitalization Reports
216
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 2 | DIZZINESS | 99 |
| 3 | INSOMNIA | 83 |
| 4 | WEIGHT INCREASED | 76 |
| 5 | ANXIETY | 68 |
| 6 | FATIGUE | 66 |
| 7 | DYSKINESIA | 51 |
| 8 | NAUSEA | 50 |
| 9 | SUICIDAL IDEATION | 48 |
| 10 | DYSPNOEA | 47 |
| 11 | SOMNOLENCE | 47 |
| 12 | AGGRESSION | 45 |
| 14 | SPEECH DISORDER | 40 |
| 15 | VOMITING | 40 |
| 16 | FALL | 38 |
| 17 | TACHYCARDIA | 38 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Fanapt may increase the risk of death in elderly patients who have psychosis related to dementia. Fanapt is not approved to treat this condition.
Known Drug Interactions
Coadministration of paroxetine with iloperidone resulted in increased mean steady-state peak concentrations of iloperidone and its metabolite P88, by about 1.6- fold, and decreased mean steady-state peak concentrations of its metabolite P95 by one-half [see Clinical Pharmacology (12.3 , 12.5) ] . Concomitant use of Strong CYP2D6 and Strong CYP3A4 Inhibitors Clinical Impact Coadministration of iloperidone with paroxetine and ketoconazole resulted in a 1.4- fold increase in steady-state concentrations of iloperidone and its metabolite P88 and a 1.4- fold decrease in the P95 in the presence...
Mechanism: Paroxetine blocks a liver protein that usually breaks down iloperidone, which causes the drug to stay in your body longer.
Strong CYP3A4 Inhibitors Clinical Impact Co-administration of ketoconazole with iloperidone, increased the AUC of iloperidone and its metabolites P88 and P95 by 57%, 55%, and 35%, respectively [see Clinical Pharmacology (12.3) ] . Concomitant use of Strong CYP2D6 and Strong CYP3A4 Inhibitors Clinical Impact Coadministration of iloperidone with paroxetine and ketoconazole resulted in a 1.4- fold increase in steady-state concentrations of iloperidone and its metabolite P88 and a 1.4- fold decrease in the P95 in the presence of paroxetine [see Clinical Pharmacology (12.3) ] .
Mechanism: Ketoconazole stops a liver enzyme from clearing iloperidone, which increases the amount of medicine in your bloodstream.
Drugs that cause QT prolongation include: specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, thioridazine, mesoridazine, droperidol, and pimozide), specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin), Class 1A antiarrhythmics (e.g., quinidine, procainamide) or Class III antiarrhythmics (e.g., amiodarone, sotalol), and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus) [see Warnings and Precautions (5.9) ] .
Mechanism: Taking these two drugs together can increase the risk of heart rhythm problems because both affect the heart's electrical timing.
These include: specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol); specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin); Class 1A antiarrhythmic medications (e.g., quinidine, procainamide); Class III antiarrhythmics (e.g., amiodarone, sotalol); and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus).
Mechanism: Both of these drugs can change the way your heart beats, which may lead to serious heart rhythm problems.
aripiprazole, brexpiprazole, cariprazine, iloperidone, lumateperone, pimavanserin ↑ aripiprazole ↑ brexpiprazole ↑ cariprazine ↑ iloperidone ↑ lumateperone ↑ pimavanserin Dosage adjustment of aripiprazole, brexpiprazole, cariprazine, iloperidone, lumateperone, and pimavanserin is recommended.
Mechanism: Ritonavir slows down the process your body uses to remove iloperidone, which increases the amount of medicine in your blood.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
Can I take Fanapt with food?
What should I do if I feel dizzy after taking Fanapt?
How long will it take for Fanapt to start working?
Can I stop taking Fanapt suddenly?
Will Fanapt make me gain weight?
Can I drink alcohol while taking Fanapt?
What if I have trouble swallowing the pill?
Does Fanapt interact with other medications?
Can Fanapt cause diabetes?
What do I do if I have muscle stiffness or tremors?
What are the common side effects of iloperidone?
Does iloperidone interact with other medications?
What drug class is iloperidone?
What pregnancy or breastfeeding source fields are listed for iloperidone?
Related Medications in Atypical Antipsychotic
Other drugs grouped near iloperidone - same-class peers and common alternatives.
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alprazolam
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amitriptyline
Elavil
Amitriptyline is a medicine used to treat depression.
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amphetamine/dextroamphetamine
Adderall, Adderall XR
Adderall XR is a stimulant medicine.
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aripiprazole
Abilify
Aripiprazole (Abilify) is a medicine used to treat certain mental disorders and mood problems.
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Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for iloperidone: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 1,388.
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 4.25%.
- colestipol Δ 0.03 pts · 2,477 reports · Bile Acid Sequestrant 4.28%death share
- adalimumab Δ 0.09 pts · 695,825 reports · TNF-Alpha Inhibitor (Biologic) 4.16%death share
- loratadine Δ 0.10 pts · 104,378 reports · Second-Generation Antihistamine 4.35%death share
- naltrexone Δ 0.11 pts · 29,813 reports · Opioid Antagonist 4.36%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for iloperidone
The FDA label for iloperidone (sold under brand names such as Fanapt) classifies it as a prescription-only medication in the Atypical Antipsychotic class. Fanapt is used to treat schizophrenia in adults. Official labeling lists 8 commonly reported side effects, including Dizziness, Dry mouth, Feeling tired.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 1,388 voluntary reports. The database also lists 5 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated minor severity. NADAC pricing from CMS.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: June 30, 2025
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages