Suvorexant and Fluconazole Interaction
Drug interaction information between Suvorexant and Fluconazole.
Suvorexant and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Suvorexant and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole blocks the enzyme that clears suvorexant from your system, making the sleep medicine stay in your body longer.
FDA Label Information
The recommended dose of BELSOMRA is 5 mg in subjects receiving moderate CYP3A inhibitors (e.g., amprenavir, aprepitant, atazanavir, ciprofloxacin, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, imatinib, verapamil).
Suvorexant Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Posaconazole moderate
- Nirmatrelvir/Ritonavir moderate
- Diltiazem minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Suvorexant + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Suvorexant's 15. In the minor band specifically: Suvorexant has 11 (also Diltiazem, Ciprofloxacin, Verapamil, Carbamazepine); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Suvorexant and Fluconazole?
Fluconazole blocks the enzyme that clears suvorexant from your system, making the sleep medicine stay in your body longer.
Fluconazole carries more major-labeled pairs than Suvorexant
SPL source-record counts only. This page's band is minor · classes on file: Suvorexant (Orexin Receptor Antagonist); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Suvorexant's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 11 minor · 15 total
- Other minor peers for Suvorexant
- Diltiazem
- Ciprofloxacin
- Verapamil
- Carbamazepine
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.