Suvorexant and Diltiazem Interaction
Drug interaction information between Suvorexant and Diltiazem.
Suvorexant and Diltiazem have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Suvorexant and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diltiazem blocks the enzyme that breaks down suvorexant, which can cause the sleep medicine to build up in your body.
FDA Label Information
The recommended dose of BELSOMRA is 5 mg in subjects receiving moderate CYP3A inhibitors (e.g., amprenavir, aprepitant, atazanavir, ciprofloxacin, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, imatinib, verapamil).
Suvorexant Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Posaconazole moderate
- Nirmatrelvir/Ritonavir moderate
- Ciprofloxacin minor
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Suvorexant + Diltiazem?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Suvorexant's 15. In the minor band specifically: Suvorexant has 11 (also Ciprofloxacin, Fluconazole, Verapamil, Carbamazepine); Diltiazem has 35 (also Buspirone, Pravastatin, Lovastatin, Cyclosporine).
What mechanism field is on file for Suvorexant and Diltiazem?
Diltiazem blocks the enzyme that breaks down suvorexant, which can cause the sleep medicine to build up in your body.
Diltiazem carries more major-labeled pairs than Suvorexant
SPL source-record counts only. This page's band is minor · classes on file: Suvorexant (Orexin Receptor Antagonist); Diltiazem (Calcium Channel Blocker).
Diltiazem has 4 major-labeled pairs vs Suvorexant's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 11 minor · 15 total
- Other minor peers for Suvorexant
- Ciprofloxacin
- Fluconazole
- Verapamil
- Carbamazepine
4 major · 7 moderate · 35 minor · 46 total
- Other minor peers for Diltiazem
- Buspirone
- Pravastatin
- Lovastatin
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.