Fluconazole and Atorvastatin Interaction
Drug interaction information between Fluconazole and Atorvastatin.
Fluconazole and Atorvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fluconazole and Atorvastatin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Fluconazole changes how your body processes atorvastatin, which can lead to a dangerous buildup and cause muscle damage.
What To Do
Your doctor may need to adjust your dosage or monitor you closely for muscle pain and weakness.
FDA Label Information
HMG-CoA reductase inhibitors : The risk of myopathy and rhabdomyolysis increases when fluconazole is coadministered with HMG-CoA reductase inhibitors metabolized through CYP3A4, such as atorvastatin and simvastatin, or through CYP2C9, such as fluvastatin.
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Simvastatin moderate
- Carbamazepine moderate
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
Can I take Fluconazole and Atorvastatin together?
This is a moderate interaction. Your doctor may need to adjust your dosage or monitor you closely for muscle pain and weakness.
How serious is the interaction between Fluconazole and Atorvastatin?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Fluconazole and Atorvastatin interact?
Fluconazole changes how your body processes atorvastatin, which can lead to a dangerous buildup and cause muscle damage.
Understanding the Fluconazole and Atorvastatin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Fluconazole belongs to the Azole Antifungal class and Atorvastatin belongs to the HMG-CoA Reductase Inhibitor (Statin) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Fluconazole changes how your body processes atorvastatin, which can lead to a dangerous buildup and cause muscle damage. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Fluconazole has 67 total documented interactions on file in this dataset, and Atorvastatin has 36. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to adjust your dosage or monitor you closely for muscle pain and weakness. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Fluconazole or Atorvastatin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.