Suvorexant and Ciprofloxacin Interaction
Drug interaction information between Suvorexant and Ciprofloxacin.
Suvorexant and Ciprofloxacin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Suvorexant and Ciprofloxacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ciprofloxacin slows down how your body breaks down suvorexant, which can lead to higher levels of the sleep medicine in your blood.
FDA Label Information
The recommended dose of BELSOMRA is 5 mg in subjects receiving moderate CYP3A inhibitors (e.g., amprenavir, aprepitant, atazanavir, ciprofloxacin, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, imatinib, verapamil).
Suvorexant Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Posaconazole moderate
- Nirmatrelvir/Ritonavir moderate
- Diltiazem minor
Ciprofloxacin Also Interacts With
- Tizanidine major
- Cyclosporine minor
- Theophylline minor
- Carbamazepine minor
- Clozapine minor
Frequently Asked Questions
What SPL severity band is on file for Suvorexant + Ciprofloxacin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Suvorexant has 15 labeled pairs on file vs Ciprofloxacin's 14. In the minor band specifically: Suvorexant has 11 (also Diltiazem, Fluconazole, Verapamil, Carbamazepine); Ciprofloxacin has 13 (also Cyclosporine, Theophylline, Carbamazepine, Clozapine).
What mechanism field is on file for Suvorexant and Ciprofloxacin?
Ciprofloxacin slows down how your body breaks down suvorexant, which can lead to higher levels of the sleep medicine in your blood.
Ciprofloxacin carries more major-labeled pairs than Suvorexant
SPL source-record counts only. This page's band is minor · classes on file: Suvorexant (Orexin Receptor Antagonist); Ciprofloxacin (Fluoroquinolone Antibiotic).
Ciprofloxacin has 1 major-labeled pair vs Suvorexant's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 11 minor · 15 total
- Other minor peers for Suvorexant
- Diltiazem
- Fluconazole
- Verapamil
- Carbamazepine
1 major · 0 moderate · 13 minor · 14 total
- Other minor peers for Ciprofloxacin
- Cyclosporine
- Theophylline
- Carbamazepine
- Clozapine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.