Fluconazole and Amlodipine Interaction
Drug interaction information between Fluconazole and Amlodipine.
Fluconazole and Amlodipine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fluconazole and Amlodipine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole blocks the enzymes that break down amlodipine, which can lead to higher levels of the blood pressure medicine in your body.
FDA Label Information
Calcium channel blockers : Certain calcium channel antagonists (nifedipine, isradipine, amlodipine, verapamil, and felodipine) are metabolized by CYP3A4.
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Amlodipine Also Interacts With
- Simvastatin major
- Amlodipine/Benazepril major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir moderate
Frequently Asked Questions
What SPL severity band is on file for Fluconazole + Amlodipine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Amlodipine's 15. In the minor band specifically: Fluconazole has 57 (also Losartan, Hydrochlorothiazide, Meloxicam, Ibuprofen); Amlodipine has 10 (also Sildenafil, Cyclosporine, Amlodipine/Valsartan, Clarithromycin).
What mechanism field is on file for Fluconazole and Amlodipine?
Fluconazole blocks the enzymes that break down amlodipine, which can lead to higher levels of the blood pressure medicine in your body.
Amlodipine carries more major-labeled pairs than Fluconazole
SPL source-record counts only. This page's band is minor · classes on file: Fluconazole (Azole Antifungal); Amlodipine (Calcium Channel Blocker).
Amlodipine has 4 major-labeled pairs vs Fluconazole's 3. This page itself is in the minor band, not the major band.
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Losartan
- Hydrochlorothiazide
- Meloxicam
- Ibuprofen
4 major · 1 moderate · 10 minor · 15 total
- Other minor peers for Amlodipine
- Sildenafil
- Cyclosporine
- Amlodipine/Valsartan
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.