Fluconazole and Eplerenone Interaction
Drug interaction information between Fluconazole and Eplerenone.
Fluconazole and Eplerenone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Fluconazole and Eplerenone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole blocks the enzyme that clears eplerenone from your body, which can lead to higher levels of the drug in your blood.
FDA Label Information
7 DRUG INTERACTIONS • CYP3A Inhibitors: In post-MI HFrEF patients, do not exceed 25 mg once daily when used with moderate CYP3A inhibitors (e.g., verapamil, erythromycin, saquinavir, fluconazole).
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Atorvastatin moderate
- Simvastatin moderate
- Carbamazepine moderate
Eplerenone Also Interacts With
- Verapamil major
- Erythromycin major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Lithium minor
Frequently Asked Questions
What SPL severity band is on file for Fluconazole + Eplerenone?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Eplerenone's 12. In the major band specifically: Fluconazole has 3 (also Pimozide, Clarithromycin); Eplerenone has 5 (also Verapamil, Erythromycin, Itraconazole, Nirmatrelvir/Ritonavir).
What mechanism field is on file for Fluconazole and Eplerenone?
Fluconazole blocks the enzyme that clears eplerenone from your body, which can lead to higher levels of the drug in your blood.
Eplerenone carries more major-labeled pairs than Fluconazole
SPL source-record counts only. This page's band is major · classes on file: Fluconazole (Azole Antifungal); Eplerenone (Aldosterone Antagonist).
Eplerenone has 5 major-labeled pairs vs Fluconazole's 3.
3 major · 7 moderate · 57 minor · 67 total
- Other major peers for Fluconazole
- Pimozide
- Clarithromycin
5 major · 0 moderate · 7 minor · 12 total
- Other major peers for Eplerenone
- Verapamil
- Erythromycin
- Itraconazole
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.