Fluconazole and Clarithromycin Interaction
Drug interaction information between Fluconazole and Clarithromycin.
Fluconazole and Clarithromycin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Fluconazole and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not significantly affect each other's levels in the body.
FDA Label Information
Fluconazole No Dose Adjustment Fluconazole: [see Pharmacokinetics ( 12.3 )] Anti-Gout Agents: Colchicine (in patients with renal or hepatic impairment) Contraindicated Colchicine: Colchicine is a substrate for both CYP3A and the efflux transporter, P-glycoprotein (Pgp).
Fluconazole Also Interacts With
- Pimozide major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
- Carbamazepine moderate
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Cyclosporine major
- Lurasidone major
- Pimozide major
Frequently Asked Questions
What SPL severity band is on file for Fluconazole + Clarithromycin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Fluconazole's 67. In the major band specifically: Fluconazole has 3 (also Pimozide, Eplerenone); Clarithromycin has 16 (also Quetiapine, Pioglitazone, Cyclosporine, Lurasidone).
What mechanism field is on file for Fluconazole and Clarithromycin?
These two drugs do not significantly affect each other's levels in the body.
Clarithromycin carries more major-labeled pairs than Fluconazole
SPL source-record counts only. This page's band is major · classes on file: Fluconazole (Azole Antifungal); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Fluconazole's 3.
3 major · 7 moderate · 57 minor · 67 total
- Other major peers for Fluconazole
- Pimozide
- Eplerenone
16 major · 35 moderate · 30 minor · 81 total
- Other major peers for Clarithromycin
- Quetiapine
- Pioglitazone
- Cyclosporine
- Lurasidone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.