What the FDA labels say about taking them together
Clarithromycin and suvorexant
Suvorexant's FDA label of March 10, 2025 names clarithromycin in its drug interactions section; the clarithromycin label PlainMeds reads does not name suvorexant. The suvorexant label: “CYP3A Inhibitors Concomitant use of BELSOMRA with strong inhibitors of CYP3A is not recommended.”
Check it at the source: the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation); the suvorexant FDA label on DailyMed (effective March 10, 2025, Merck Sharp & Dohme LLC).
What does the clarithromycin label say about suvorexant?
Clarithromycin's label (effective April 9, 2026) does not name suvorexant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed
What does the suvorexant label say about clarithromycin?
Suvorexant label, drug interactionsCYP3A Inhibitors Concomitant use of BELSOMRA with strong inhibitors of CYP3A (e.g., ketoconazole, itraconazole, posaconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, boceprevir, telaprevir, telithromycin and conivaptan) is not recommended [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (BELSOMRA), Merck Sharp & Dohme LLC, effective March 10, 2025 (SPL set e5b72731-1acb-45b7-9c13-290ad12d3951), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clarithromycin | Suvorexant | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | Insomnia |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.466 per tablet 500 mg tablet | $15.21 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once