Suvorexant and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Suvorexant and Nirmatrelvir/Ritonavir.
Suvorexant and Nirmatrelvir/Ritonavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Suvorexant and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ritonavir slows down how quickly your body clears suvorexant, which can make the effects of the sleep medicine much stronger.
FDA Label Information
Neuropsychiatric agents suvorexant ↑ suvorexant Avoid concomitant use of suvorexant with PAXLOVID.
Suvorexant Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Posaconazole moderate
- Diltiazem minor
- Ciprofloxacin minor
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Suvorexant + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Suvorexant's 15. In the moderate band specifically: Suvorexant has 4 (also Ketoconazole, Clarithromycin, Posaconazole); Nirmatrelvir/Ritonavir has 30 (also Amlodipine, Tamsulosin, Fluticasone, Apixaban).
What mechanism field is on file for Suvorexant and Nirmatrelvir/Ritonavir?
Ritonavir slows down how quickly your body clears suvorexant, which can make the effects of the sleep medicine much stronger.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Suvorexant
SPL source-record counts only. This page's band is moderate · classes on file: Suvorexant (Orexin Receptor Antagonist); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Suvorexant's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 11 minor · 15 total
- Other moderate peers for Suvorexant
- Ketoconazole
- Clarithromycin
- Posaconazole
23 major · 30 moderate · 33 minor · 86 total
- Other moderate peers for Nirmatrelvir/Ritonavir
- Amlodipine
- Tamsulosin
- Fluticasone
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.