Suvorexant and Posaconazole Interaction
Drug interaction information between Suvorexant and Posaconazole.
Suvorexant and Posaconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Suvorexant and Posaconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Posaconazole stops your body from clearing suvorexant, which can lead to higher levels of the sleep medicine in your system than intended.
FDA Label Information
CYP3A Inhibitors Concomitant use of BELSOMRA with strong inhibitors of CYP3A (e.g., ketoconazole, itraconazole, posaconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, boceprevir, telaprevir, telithromycin and conivaptan) is not recommended [see Clinical Pharmacology (12.3) ].
Suvorexant Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Nirmatrelvir/Ritonavir moderate
- Diltiazem minor
- Ciprofloxacin minor
Posaconazole Also Interacts With
- Esomeprazole major
- Digoxin major
- Cimetidine major
- Metoclopramide major
- Phenytoin major
Frequently Asked Questions
What SPL severity band is on file for Suvorexant + Posaconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Posaconazole has 27 labeled pairs on file vs Suvorexant's 15. In the moderate band specifically: Suvorexant has 4 (also Ketoconazole, Clarithromycin, Nirmatrelvir/Ritonavir); Posaconazole has 5 (also Efavirenz, Lovastatin, Tacrolimus Topical, Vorapaxar).
What mechanism field is on file for Suvorexant and Posaconazole?
Posaconazole stops your body from clearing suvorexant, which can lead to higher levels of the sleep medicine in your system than intended.
Posaconazole carries more major-labeled pairs than Suvorexant
SPL source-record counts only. This page's band is moderate · classes on file: Suvorexant (Orexin Receptor Antagonist); Posaconazole (Azole Antifungal).
Posaconazole has 5 major-labeled pairs vs Suvorexant's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 11 minor · 15 total
- Other moderate peers for Suvorexant
- Ketoconazole
- Clarithromycin
- Nirmatrelvir/Ritonavir
5 major · 5 moderate · 17 minor · 27 total
- Other moderate peers for Posaconazole
- Efavirenz
- Lovastatin
- Tacrolimus Topical
- Vorapaxar
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.