What the FDA labels say about taking them together
Posaconazole and suvorexant
Suvorexant's FDA label of March 10, 2025 names posaconazole in its drug interactions section; the posaconazole labels PlainMeds reads (2) do not name suvorexant. The suvorexant label: “CYP3A Inhibitors Concomitant use of BELSOMRA with strong inhibitors of CYP3A is not recommended.”
Check it at the source: the posaconazole FDA label on DailyMed (effective August 3, 2026, Aurobindo Pharma Limited); the suvorexant FDA label on DailyMed (effective March 10, 2025, Merck Sharp & Dohme LLC).
What does the posaconazole label say about suvorexant?
Posaconazole's label (effective August 3, 2026) and its 1 other brand-application label do not name suvorexant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (POSACONAZOLE), Aurobindo Pharma Limited, effective August 3, 2026 (SPL set f8a26673-261c-4e8e-b1e1-9e23aaf7f285), via openFDA; the full label on DailyMed
What does the suvorexant label say about posaconazole?
Suvorexant label, drug interactionsCYP3A Inhibitors Concomitant use of BELSOMRA with strong inhibitors of CYP3A (e.g., ketoconazole, itraconazole, posaconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, boceprevir, telaprevir, telithromycin and conivaptan) is not recommended [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (BELSOMRA), Merck Sharp & Dohme LLC, effective March 10, 2025 (SPL set e5b72731-1acb-45b7-9c13-290ad12d3951), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Posaconazole | Suvorexant | |
|---|---|---|
| Labeled for | Fungal infections | Insomnia |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $2.03 per tablet 100 mg tablet | $15.21 per tablet 10 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once