Suvorexant and Verapamil Interaction
Drug interaction information between Suvorexant and Verapamil.
Suvorexant and Verapamil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Suvorexant and Verapamil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Verapamil interferes with the way your liver processes suvorexant, which can increase the amount of medicine in your body.
FDA Label Information
The recommended dose of BELSOMRA is 5 mg in subjects receiving moderate CYP3A inhibitors (e.g., amprenavir, aprepitant, atazanavir, ciprofloxacin, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, imatinib, verapamil).
Suvorexant Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Posaconazole moderate
- Nirmatrelvir/Ritonavir moderate
- Diltiazem minor
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Suvorexant + Verapamil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Suvorexant's 15. In the minor band specifically: Suvorexant has 11 (also Diltiazem, Ciprofloxacin, Fluconazole, Carbamazepine); Verapamil has 47 (also Atorvastatin, Aspirin, Atenolol, Timolol).
What mechanism field is on file for Suvorexant and Verapamil?
Verapamil interferes with the way your liver processes suvorexant, which can increase the amount of medicine in your body.
Verapamil carries more major-labeled pairs than Suvorexant
SPL source-record counts only. This page's band is minor · classes on file: Suvorexant (Orexin Receptor Antagonist); Verapamil (Calcium Channel Blocker).
Verapamil has 4 major-labeled pairs vs Suvorexant's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 11 minor · 15 total
- Other minor peers for Suvorexant
- Diltiazem
- Ciprofloxacin
- Fluconazole
- Carbamazepine
4 major · 6 moderate · 47 minor · 57 total
- Other minor peers for Verapamil
- Atorvastatin
- Aspirin
- Atenolol
- Timolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.