Fluconazole and Simvastatin Interaction
Drug interaction information between Fluconazole and Simvastatin.
Fluconazole and Simvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fluconazole and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole blocks the enzyme that breaks down simvastatin, causing the cholesterol medicine to build up in your body. This increases the risk of serious muscle damage.
FDA Label Information
HMG-CoA reductase inhibitors : The risk of myopathy and rhabdomyolysis increases when fluconazole is coadministered with HMG-CoA reductase inhibitors metabolized through CYP3A4, such as atorvastatin and simvastatin, or through CYP2C9, such as fluvastatin.
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Carbamazepine moderate
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Fluconazole + Simvastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Simvastatin's 41. In the moderate band specifically: Fluconazole has 7 (also Atorvastatin, Carbamazepine, Amiodarone, Fluvastatin); Simvastatin has 9 (also Ezetimibe, Daptomycin, Colchicine, Niacin).
What mechanism field is on file for Fluconazole and Simvastatin?
Fluconazole blocks the enzyme that breaks down simvastatin, causing the cholesterol medicine to build up in your body. This increases the risk of serious muscle damage.
Simvastatin carries more major-labeled pairs than Fluconazole
SPL source-record counts only. This page's band is moderate · classes on file: Fluconazole (Azole Antifungal); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Simvastatin has 11 major-labeled pairs vs Fluconazole's 3. This page itself is in the moderate band, not the major band.
3 major · 7 moderate · 57 minor · 67 total
- Other moderate peers for Fluconazole
- Atorvastatin
- Carbamazepine
- Amiodarone
- Fluvastatin
11 major · 9 moderate · 21 minor · 41 total
- Other moderate peers for Simvastatin
- Ezetimibe
- Daptomycin
- Colchicine
- Niacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.