Fluconazole and Meloxicam Interaction
Drug interaction information between Fluconazole and Meloxicam.
Fluconazole and Meloxicam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fluconazole and Meloxicam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole blocks the enzymes that break down this pain medicine, which can cause the medicine to build up in your body.
FDA Label Information
Although not specifically studied, fluconazole has the potential to increase the systemic exposure of other non-steroidal anti-inflammatory drugs (NSAIDs) that are metabolized by CYP2C9 (e.g., naproxen, lornoxicam, meloxicam, diclofenac).
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Meloxicam Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Furosemide minor
- Aspirin minor
- Propranolol minor
Frequently Asked Questions
What SPL severity band is on file for Fluconazole + Meloxicam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Meloxicam's 17. In the minor band specifically: Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Ibuprofen); Meloxicam has 15 (also Furosemide, Aspirin, Propranolol, Warfarin).
What mechanism field is on file for Fluconazole and Meloxicam?
Fluconazole blocks the enzymes that break down this pain medicine, which can cause the medicine to build up in your body.
Fluconazole carries more major-labeled pairs than Meloxicam
SPL source-record counts only. This page's band is minor · classes on file: Fluconazole (Azole Antifungal); Meloxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
Fluconazole has 3 major-labeled pairs vs Meloxicam's 0. This page itself is in the minor band, not the major band.
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Ibuprofen
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Meloxicam
- Furosemide
- Aspirin
- Propranolol
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.