What the FDA labels say about taking them together
Fluconazole and hydrochlorothiazide
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names hydrochlorothiazide in its drug interactions section; the hydrochlorothiazide labels PlainMeds reads (3) do not name fluconazole. The fluconazole label: “Hydrochlorothiazide In a pharmacokinetic interaction study, coadministration of multiple-dose hydrochlorothiazide to healthy volunteers receiving fluconazole increased plasma concentrations of fluconazole by 40%.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the hydrochlorothiazide FDA label on DailyMed (effective June 12, 2026, Leading Pharma, LLC).
What does the fluconazole label say about hydrochlorothiazide?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsHydrochlorothiazide In a pharmacokinetic interaction study, coadministration of multiple-dose hydrochlorothiazide to healthy volunteers receiving fluconazole increased plasma concentrations of fluconazole by 40%.
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the hydrochlorothiazide label say about fluconazole?
Hydrochlorothiazide's label (effective June 12, 2026) and its 2 other brand-application labels do not name fluconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (HYDROCHLOROTHIAZIDE), Leading Pharma, LLC, effective June 12, 2026 (SPL set 8c868894-667e-4a51-906a-838d63e420ba), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Hydrochlorothiazide | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | Heart failure, High blood pressure, Edema (fluid retention) |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | $0.0115 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once