Diltiazem and Ezetimibe Interaction
Drug interaction information between Diltiazem and Ezetimibe.
Diltiazem and Ezetimibe have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Diltiazem and Ezetimibe. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diltiazem can increase the levels of the cholesterol medicine in your blood, which may lead to muscle problems.
FDA Label Information
Intervention: For patients taking verapamil, diltiazem, or dronedarone, do not exceed ezetimibe and simvastatin 10 mg/10 mg daily.
Diltiazem Also Interacts With
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
- Digoxin moderate
Ezetimibe Also Interacts With
- Amlodipine major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Diltiazem + Ezetimibe?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Ezetimibe's 25. In the major band specifically: Diltiazem has 4 (also Ezetimibe/Simvastatin, Simvastatin, Theophylline); Ezetimibe has 8 (also Amlodipine, Verapamil, Cyclosporine, Amiodarone).
What mechanism field is on file for Diltiazem and Ezetimibe?
Diltiazem can increase the levels of the cholesterol medicine in your blood, which may lead to muscle problems.
Ezetimibe carries more major-labeled pairs than Diltiazem
SPL source-record counts only. This page's band is major · classes on file: Diltiazem (Calcium Channel Blocker); Ezetimibe (Cholesterol Absorption Inhibitor).
Ezetimibe has 8 major-labeled pairs vs Diltiazem's 4.
4 major · 7 moderate · 35 minor · 46 total
- Other major peers for Diltiazem
- Ezetimibe/Simvastatin
- Simvastatin
- Theophylline
8 major · 4 moderate · 13 minor · 25 total
- Other major peers for Ezetimibe
- Amlodipine
- Verapamil
- Cyclosporine
- Amiodarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.