Diltiazem and Lovastatin Interaction
Drug interaction information between Diltiazem and Lovastatin.
Diltiazem and Lovastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Diltiazem and Lovastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diltiazem blocks the enzymes that normally break down lovastatin, leading to higher amounts of the drug in your body.
FDA Label Information
In a ten-subject randomized, open-label, 4-way crossover study, coadministration of diltiazem (120 mg BID diltiazem SR for 2 weeks) with a single 20 mg dose of lovastatin resulted in 3- to 4-fold increase in mean lovastatin AUC and C max versus lovastatin alone. Diltiazem plasma levels were not significantly affected by lovastatin or pravastatin.
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Lovastatin Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Spironolactone moderate
- Ketoconazole moderate
- Verapamil moderate
Frequently Asked Questions
What SPL severity band is on file for Diltiazem + Lovastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Lovastatin's 30. In the minor band specifically: Diltiazem has 35 (also Buspirone, Pravastatin, Cyclosporine, Carbamazepine); Lovastatin has 11 (also Glipizide, Propranolol, Warfarin, Testosterone).
What mechanism field is on file for Diltiazem and Lovastatin?
Diltiazem blocks the enzymes that normally break down lovastatin, leading to higher amounts of the drug in your body.
Diltiazem carries more major-labeled pairs than Lovastatin
SPL source-record counts only. This page's band is minor · classes on file: Diltiazem (Calcium Channel Blocker); Lovastatin (HMG-CoA Reductase Inhibitor (Statin)).
Diltiazem has 4 major-labeled pairs vs Lovastatin's 2. This page itself is in the minor band, not the major band.
4 major · 7 moderate · 35 minor · 46 total
- Other minor peers for Diltiazem
- Buspirone
- Pravastatin
- Cyclosporine
- Carbamazepine
2 major · 17 moderate · 11 minor · 30 total
- Other minor peers for Lovastatin
- Glipizide
- Propranolol
- Warfarin
- Testosterone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.