What the FDA labels say about taking them together
Diltiazem and lovastatin
Diltiazem's FDA label of August 7, 2026 names lovastatin in its drug interactions section, and lovastatin's label names diltiazem too. The diltiazem label: “In a ten-subject randomized, open-label, 4-way crossover study, coadministration of diltiazem with a single 20 mg dose of lovastatin resulted in 3- to 4-fold increase in mean lovastatin AUC and C max versus lovastatin …”
Check it at the source: the diltiazem FDA label on DailyMed (effective August 7, 2026, Bausch Health US, LLC); the lovastatin FDA label on DailyMed (effective May 6, 2026, Lupin Pharmaceuticals, Inc.).
What does the diltiazem label say about lovastatin?
Diltiazem label, drug interactionsIn a ten-subject randomized, open-label, 4-way cross-over study, coadministration of diltiazem (120 mg BID diltiazem SR for 2 weeks) with a single 20 mg dose of lovastatin resulted in 3- to 4-fold increase in mean lovastatin AUC and C max versus lovastatin alone.
Source: FDA drug label (Cardizem Cd, NDA020062), Bausch Health US LLC, effective December 10, 2025 (SPL set 1042fa13-e6af-46b9-8008-6c941f0978b1), via openFDA
Source: FDA drug label (TIAZAC EXTENDED RELEASE), Bausch Health US, LLC, effective August 7, 2026 (SPL set c567fe7e-887e-4291-a0d1-2dd3f25cbf25), via openFDA; the full label on DailyMed
What does the lovastatin label say about diltiazem?
Lovastatin label, warningsDanazol, diltiazem, dronedarone or verapamil with higher doses of lovastatin The dose of lovastatin should not exceed 20 mg daily in patients receiving concomitant medication with danazol, diltiazem, dronedarone, or verapamil.
Source: FDA drug label (Lovastatin), Lupin Pharmaceuticals, Inc., effective May 6, 2026 (SPL set df7ddf4f-d569-431e-81f1-9129d7043150), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diltiazem | Lovastatin | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Atrial fibrillation | High cholesterol, Heart attack and coronary artery disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.144 per capsule 24h ER(cd) 120 mg capsule | $0.0436 per tablet 20 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once