Diltiazem and Buspirone Interaction
Drug interaction information between Diltiazem and Buspirone.
Diltiazem and Buspirone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Diltiazem and Buspirone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diltiazem prevents the body from breaking down buspirone properly, which causes buspirone levels to rise significantly.
FDA Label Information
Buspirone : In nine healthy subjects, diltiazem significantly increased the mean buspirone AUC 5.5-fold and C max 4.1-fold compared to placebo. The T 1/2 and T max of buspirone were not significantly affected by diltiazem. Enhanced effects and increased toxicity of buspirone may be possible during concomitant administration with diltiazem.
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Citalopram minor
- Darunavir minor
- Desvenlafaxine minor
Frequently Asked Questions
What SPL severity band is on file for Diltiazem + Buspirone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Buspirone's 17. In the minor band specifically: Diltiazem has 35 (also Pravastatin, Lovastatin, Cyclosporine, Carbamazepine); Buspirone has 15 (also Citalopram, Darunavir, Desvenlafaxine, Diphenoxylate/Atropine).
What mechanism field is on file for Diltiazem and Buspirone?
Diltiazem prevents the body from breaking down buspirone properly, which causes buspirone levels to rise significantly.
Diltiazem carries more major-labeled pairs than Buspirone
SPL source-record counts only. This page's band is minor · classes on file: Diltiazem (Calcium Channel Blocker); Buspirone (Azapirone Anxiolytic).
Diltiazem has 4 major-labeled pairs vs Buspirone's 0. This page itself is in the minor band, not the major band.
4 major · 7 moderate · 35 minor · 46 total
- Other minor peers for Diltiazem
- Pravastatin
- Lovastatin
- Cyclosporine
- Carbamazepine
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Buspirone
- Citalopram
- Darunavir
- Desvenlafaxine
- Diphenoxylate/Atropine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.