Diltiazem and Ezetimibe/Simvastatin Interaction
Drug interaction information between Diltiazem and Ezetimibe/Simvastatin.
Diltiazem and Ezetimibe/Simvastatin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Diltiazem and Ezetimibe/Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diltiazem slows down the breakdown of simvastatin in your body, which can lead to higher levels of the drug in your blood. This increases the risk of serious muscle damage.
FDA Label Information
Intervention: For patients taking verapamil, diltiazem, or dronedarone, do not exceed VYTORIN 10/10 mg daily.
Diltiazem Also Interacts With
- Ezetimibe major
- Simvastatin major
- Theophylline major
- Rifampin moderate
- Digoxin moderate
Ezetimibe/Simvastatin Also Interacts With
- Amlodipine major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Diltiazem + Ezetimibe/Simvastatin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Ezetimibe/Simvastatin's 23. In the major band specifically: Diltiazem has 4 (also Ezetimibe, Simvastatin, Theophylline); Ezetimibe/Simvastatin has 8 (also Amlodipine, Verapamil, Cyclosporine, Amiodarone).
What mechanism field is on file for Diltiazem and Ezetimibe/Simvastatin?
Diltiazem slows down the breakdown of simvastatin in your body, which can lead to higher levels of the drug in your blood. This increases the risk of serious muscle damage.
Ezetimibe/Simvastatin carries more major-labeled pairs than Diltiazem
SPL source-record counts only. This page's band is major · classes on file: Diltiazem (Calcium Channel Blocker); Ezetimibe/Simvastatin (Cholesterol Absorption Inhibitor / Statin Combination).
Ezetimibe/Simvastatin has 8 major-labeled pairs vs Diltiazem's 4.
4 major · 7 moderate · 35 minor · 46 total
- Other major peers for Diltiazem
- Ezetimibe
- Simvastatin
- Theophylline
8 major · 4 moderate · 11 minor · 23 total
- Other major peers for Ezetimibe/Simvastatin
- Amlodipine
- Verapamil
- Cyclosporine
- Amiodarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.