Diltiazem and Rifampin Interaction
Drug interaction information between Diltiazem and Rifampin.
Diltiazem and Rifampin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Diltiazem and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up how quickly your body breaks down diltiazem, which can cause the diltiazem to disappear from your blood and stop working.
FDA Label Information
Rifampin : Coadministration of rifampin with diltiazem lowered the diltiazem plasma concentrations to undetectable levels. Avoid coadministration of diltiazem with rifampin or any known CYP3A4 inducer.
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Digoxin moderate
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Diltiazem + Rifampin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Diltiazem's 46. In the moderate band specifically: Diltiazem has 7 (also Digoxin, Ivabradine, Aprepitant, Metoprolol); Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban).
What mechanism field is on file for Diltiazem and Rifampin?
Rifampin speeds up how quickly your body breaks down diltiazem, which can cause the diltiazem to disappear from your blood and stop working.
Rifampin carries more major-labeled pairs than Diltiazem
SPL source-record counts only. This page's band is moderate · classes on file: Diltiazem (Calcium Channel Blocker); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Diltiazem's 4. This page itself is in the moderate band, not the major band.
4 major · 7 moderate · 35 minor · 46 total
- Other moderate peers for Diltiazem
- Digoxin
- Ivabradine
- Aprepitant
- Metoprolol
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.