What the FDA labels say about taking them together
Cyclosporine and diltiazem
Cyclosporine's FDA label of August 10, 2026 names diltiazem in its drug interactions section, and diltiazem's label names cyclosporine too. The diltiazem label: “In renal and cardiac transplant recipients, a reduction of cyclosporine trough dose ranging from 15% to 48% was necessary to maintain concentrations similar to those seen prior to the addition of diltiazem.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the diltiazem FDA label on DailyMed (effective August 7, 2026, Bausch Health US, LLC).
What does the cyclosporine label say about diltiazem?
Cyclosporine label, drug interactionsdiltiazem; fluconazole; azithromycin; methylprednisolone; Allopurinol
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the diltiazem label say about cyclosporine?
Diltiazem label, drug interactionsIn renal and cardiac transplant recipients, a reduction of cyclosporine dose ranging from 15% to 48% was necessary to maintain cyclosporine trough concentrations similar to those seen prior to the addition of diltiazem.
Cardizem label (Bausch Health US LLC, April 30, 2025), drug interactionsIn renal and cardiac transplant recipients, a reduction of cyclosporine trough dose ranging from 15% to 48% was necessary to maintain concentrations similar to those seen prior to the addition of diltiazem.
Source: FDA drug label (Cardizem, NDA018602), Bausch Health US LLC, effective April 30, 2025 (SPL set f3e7ecef-f360-4987-a4f5-933214130ab2), via openFDA
Source: FDA drug label (TIAZAC EXTENDED RELEASE), Bausch Health US, LLC, effective August 7, 2026 (SPL set c567fe7e-887e-4291-a0d1-2dd3f25cbf25), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Diltiazem | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | High blood pressure, Angina, Atrial fibrillation |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.144 per capsule 24h ER(cd) 120 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once