Posaconazole and Verapamil Interaction
Drug interaction information between Posaconazole and Verapamil.
Posaconazole and Verapamil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Posaconazole and Verapamil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Posaconazole stops the body from clearing verapamil, which can lead to higher-than-normal levels of the drug in your system.
FDA Label Information
7.11 Calcium Channel Blockers Metabolized by CYP3A4 Posaconazole may increase the plasma concentrations of calcium channel blockers metabolized by CYP3A4 (e.g., verapamil, diltiazem, nifedipine, nicardipine, felodipine).
Posaconazole Also Interacts With
- Esomeprazole major
- Digoxin major
- Cimetidine major
- Metoclopramide major
- Phenytoin major
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Posaconazole + Verapamil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Posaconazole's 27. In the minor band specifically: Posaconazole has 17 (also Alprazolam, Glipizide, Diltiazem, Nifedipine); Verapamil has 47 (also Atorvastatin, Aspirin, Atenolol, Timolol).
What mechanism field is on file for Posaconazole and Verapamil?
Posaconazole stops the body from clearing verapamil, which can lead to higher-than-normal levels of the drug in your system.
Posaconazole carries more major-labeled pairs than Verapamil
SPL source-record counts only. This page's band is minor · classes on file: Posaconazole (Azole Antifungal); Verapamil (Calcium Channel Blocker).
Posaconazole has 5 major-labeled pairs vs Verapamil's 4. This page itself is in the minor band, not the major band.
5 major · 5 moderate · 17 minor · 27 total
- Other minor peers for Posaconazole
- Alprazolam
- Glipizide
- Diltiazem
- Nifedipine
4 major · 6 moderate · 47 minor · 57 total
- Other minor peers for Verapamil
- Atorvastatin
- Aspirin
- Atenolol
- Timolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.