Posaconazole and Metoclopramide Interaction
Drug interaction information between Posaconazole and Metoclopramide.
Posaconazole and Metoclopramide have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Posaconazole and Metoclopramide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Metoclopramide speeds up how fast medicine moves through the digestive system, which can lower the amount of posaconazole that gets absorbed.
FDA Label Information
Interaction Drug Interaction Rifabutin, phenytoin, efavirenz, cimetidine, esomeprazole* Avoid coadministration unless the benefit outweighs the risks ( 7.6 , 7.7 , 7.8 , 7.9 ) Other drugs metabolized by CYP3A4 Consider dosage adjustment and monitor for adverse effects and toxicity ( 7.1 , 7.10 , 7.11 ) Digoxin Monitor digoxin plasma concentrations ( 7.12 ) Fosamprenavir, metoclopramide* Monitor for breakthrough fungal infections ( 7.6 , 7.13 ) *The drug interactions with esomeprazole and metoclopramide do not apply to posaconazole tablets. 7.13 Gastrointestinal Motility Agents Concomitant...
Posaconazole Also Interacts With
- Esomeprazole major
- Digoxin major
- Cimetidine major
- Phenytoin major
- Efavirenz/Emtricitabine/Tenofovir moderate
Metoclopramide Also Interacts With
- Lidocaine Topical moderate
- Rivastigmine moderate
- Tacrolimus Topical moderate
- Tranylcypromine moderate
- Acetaminophen minor
Frequently Asked Questions
What SPL severity band is on file for Posaconazole + Metoclopramide?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Posaconazole has 27 labeled pairs on file vs Metoclopramide's 23. In the major band specifically: Posaconazole has 5 (also Esomeprazole, Digoxin, Cimetidine, Phenytoin); Metoclopramide has 1.
What mechanism field is on file for Posaconazole and Metoclopramide?
Metoclopramide speeds up how fast medicine moves through the digestive system, which can lower the amount of posaconazole that gets absorbed.
Posaconazole carries more major-labeled pairs than Metoclopramide
SPL source-record counts only. This page's band is major · classes on file: Posaconazole (Azole Antifungal); Metoclopramide (Prokinetic / Antiemetic).
Posaconazole has 5 major-labeled pairs vs Metoclopramide's 1.
5 major · 5 moderate · 17 minor · 27 total
- Other major peers for Posaconazole
- Esomeprazole
- Digoxin
- Cimetidine
- Phenytoin
1 major · 4 moderate · 18 minor · 23 total
Metoclopramide has no other major-band peer in this dataset besides Posaconazole.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.