Posaconazole and Nifedipine Interaction
Drug interaction information between Posaconazole and Nifedipine.
Posaconazole and Nifedipine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Posaconazole and Nifedipine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Posaconazole blocks the enzyme that breaks down nifedipine, which can cause the blood pressure medicine to build up in your body.
FDA Label Information
7.11 Calcium Channel Blockers Metabolized by CYP3A4 Posaconazole may increase the plasma concentrations of calcium channel blockers metabolized by CYP3A4 (e.g., verapamil, diltiazem, nifedipine, nicardipine, felodipine).
Posaconazole Also Interacts With
- Esomeprazole major
- Digoxin major
- Cimetidine major
- Metoclopramide major
- Phenytoin major
Nifedipine Also Interacts With
- Theophylline major
- Phenytoin moderate
- Nirmatrelvir/Ritonavir moderate
- Tacrolimus Topical moderate
- Fluoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Posaconazole + Nifedipine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Posaconazole has 27 labeled pairs on file vs Nifedipine's 26. In the minor band specifically: Posaconazole has 17 (also Alprazolam, Glipizide, Diltiazem, Verapamil); Nifedipine has 22 (also Fluoxetine, Fluconazole, Erythromycin, Clarithromycin).
What mechanism field is on file for Posaconazole and Nifedipine?
Posaconazole blocks the enzyme that breaks down nifedipine, which can cause the blood pressure medicine to build up in your body.
Posaconazole carries more major-labeled pairs than Nifedipine
SPL source-record counts only. This page's band is minor · classes on file: Posaconazole (Azole Antifungal); Nifedipine (Calcium Channel Blocker).
Posaconazole has 5 major-labeled pairs vs Nifedipine's 1. This page itself is in the minor band, not the major band.
5 major · 5 moderate · 17 minor · 27 total
- Other minor peers for Posaconazole
- Alprazolam
- Glipizide
- Diltiazem
- Verapamil
1 major · 3 moderate · 22 minor · 26 total
- Other minor peers for Nifedipine
- Fluoxetine
- Fluconazole
- Erythromycin
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.