What the FDA labels say about taking them together
Cimetidine and posaconazole
Posaconazole's FDA label of August 3, 2026 names cimetidine in its drug interactions section; the cimetidine label PlainMeds reads does not name posaconazole. The posaconazole label: “Interaction Drug: Rifabutin, phenytoin, efavirenz, cimetidine, esomeprazole*; Interaction: Avoid coadministration unless the benefit outweighs the risks”
Check it at the source: the cimetidine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.); the posaconazole FDA label on DailyMed (effective August 3, 2026, Aurobindo Pharma Limited).
What does the cimetidine label say about posaconazole?
Cimetidine's label (effective July 15, 2026) does not name posaconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cimetidine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set 06c0a509-026f-44e0-9975-a94a8de51d43), via openFDA; the full label on DailyMed
What does the posaconazole label say about cimetidine?
Posaconazole label, drug interactionsInteraction Drug: Rifabutin, phenytoin, efavirenz, cimetidine, esomeprazole*; Interaction: Avoid coadministration unless the benefit outweighs the risks (,)
Noxafil label (Merck Sharp & Dohme LLC, February 13, 2026), drug interactionsInteraction Drug: Rifabutin, phenytoin, efavirenz, cimetidine, esomeprazole The drug interactions with esomeprazole and metoclopramide do not apply to Noxafil tablets or Noxafil PowderMix (,).; Interaction: Avoid coadministration unless the benefit outweighs the risks (,)
Source: FDA drug label (Noxafil, NDA022003), Merck Sharp & Dohme LLC, effective February 13, 2026 (SPL set b073b082-7b57-4423-8c06-4fd4263d6f84), via openFDA
Source: FDA drug label (POSACONAZOLE), Aurobindo Pharma Limited, effective August 3, 2026 (SPL set f8a26673-261c-4e8e-b1e1-9e23aaf7f285), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cimetidine | Posaconazole | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.236 per tablet 300 mg tablet | $2.03 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once