Verapamil and Atenolol Interaction
Drug interaction information between Verapamil and Atenolol.
Verapamil and Atenolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Verapamil and Atenolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs affect the heart and blood pressure, and taking them together can cause unpredictable changes in how your heart works.
FDA Label Information
A variable effect has been seen when verapamil and atenolol were given together.
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Atenolol Also Interacts With
- Aspirin major
- Theophylline major
- Clonidine minor
- Amiodarone minor
- Epinephrine minor
Frequently Asked Questions
What SPL severity band is on file for Verapamil + Atenolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Atenolol's 14. In the minor band specifically: Verapamil has 47 (also Atorvastatin, Aspirin, Timolol, Cyclosporine); Atenolol has 12 (also Clonidine, Amiodarone, Epinephrine, Indomethacin).
What mechanism field is on file for Verapamil and Atenolol?
Both drugs affect the heart and blood pressure, and taking them together can cause unpredictable changes in how your heart works.
Verapamil carries more major-labeled pairs than Atenolol
SPL source-record counts only. This page's band is minor · classes on file: Verapamil (Calcium Channel Blocker); Atenolol (Beta-1 Selective Blocker).
Verapamil has 4 major-labeled pairs vs Atenolol's 2. This page itself is in the minor band, not the major band.
4 major · 6 moderate · 47 minor · 57 total
- Other minor peers for Verapamil
- Atorvastatin
- Aspirin
- Timolol
- Cyclosporine
2 major · 0 moderate · 12 minor · 14 total
- Other minor peers for Atenolol
- Clonidine
- Amiodarone
- Epinephrine
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.