What the FDA labels say about taking them together
Atenolol and verapamil
Atenolol's FDA label of September 18, 2025 names verapamil in its warnings section, and verapamil's label names atenolol too. The atenolol label: “… end diastolic pressure can rise when beta-blockers are administered with verapamil or diltiazem.”
Check it at the source: the atenolol FDA label on DailyMed (effective September 18, 2025, Upsher-Smith Laboratories, LLC); the verapamil FDA label on DailyMed (effective April 6, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the atenolol label say about verapamil?
Atenolol label, warningsBecause coronary artery disease is common and may be unrecognized, it may be prudent not to discontinue TENORMIN therapy abruptly even in patients treated only for hypertension. (See DOSAGE AND ADMINISTRATION . ) Concomitant Use of Calcium Channel Blockers Bradycardia and heart block can occur and the left ventricular end diastolic pressure can rise when beta-blockers are administered with verapamil or diltiazem.
Source: FDA drug label (TENORMIN), NDA018240 (Twi Pharms), as published by Upsher-Smith Laboratories, LLC, effective September 18, 2025 (SPL set 6e850b1e-28a4-4ff8-8ed7-bb0b29faa28a), via openFDA; the full label on DailyMed
What does the verapamil label say about atenolol?
Verapamil label, drug interactionsA variable effect has been seen when verapamil and atenolol were given together.
Source: FDA drug label (Verapamil Hydrochloride, NDA019614), Wilshire Pharmaceuticals, Inc., effective November 27, 2024 (SPL set f9399858-fd7a-4b73-8759-3e5bf3af2666), via openFDA
Source: FDA drug label (Verapamil hydrochloride), Zydus Pharmaceuticals (USA) Inc., effective April 6, 2026 (SPL set e19ab8d8-dae5-489d-9805-7e7407bea06d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atenolol | Verapamil | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Heart attack and coronary artery disease | High blood pressure, Atrial fibrillation, Angina |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0217 per tablet 25 mg tablet | $0.191 per tablet 180 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once