Verapamil and Atorvastatin Interaction
Drug interaction information between Verapamil and Atorvastatin.
Verapamil and Atorvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Verapamil and Atorvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Verapamil slows down how the body breaks down atorvastatin, which can lead to higher levels of the drug in your blood.
FDA Label Information
Lower starting and maintenance doses of other CYP3A4 substrates (e.g., atorvastatin) may be required as verapamil may increase the plasma concentration of these drugs.
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Verapamil + Atorvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Atorvastatin's 36. In the minor band specifically: Verapamil has 47 (also Aspirin, Atenolol, Timolol, Cyclosporine); Atorvastatin has 25 (also Estradiol, Norethindrone, Ketoconazole, Erythromycin).
What mechanism field is on file for Verapamil and Atorvastatin?
Verapamil slows down how the body breaks down atorvastatin, which can lead to higher levels of the drug in your blood.
Verapamil carries more major-labeled pairs than Atorvastatin
SPL source-record counts only. This page's band is minor · classes on file: Verapamil (Calcium Channel Blocker); Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Verapamil has 4 major-labeled pairs vs Atorvastatin's 3. This page itself is in the minor band, not the major band.
4 major · 6 moderate · 47 minor · 57 total
- Other minor peers for Verapamil
- Aspirin
- Atenolol
- Timolol
- Cyclosporine
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Estradiol
- Norethindrone
- Ketoconazole
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.