posaconazole vs verapamil
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Side-by-side comparison of posaconazole and verapamil. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.11 Calcium Channel Blockers Metabolized by CYP3A4 Posaconazole may increase the plasma concentrations of calcium channel blockers metabolized by CYP3A4 (e.g., verapamil, diltiazem, nifedipine, nicardipine, felodipine).
Noxafil
Calan, Verelan
Posaconazole is an antifungal medicine. It helps prevent certain fungal infections in people with weakened immune systems.
Verapamil is a drug that helps to lower blood pressure and treat chest pain (angina) and irregular heartbeats (arrhythmias). It works by relaxing blood vessels and slowing down the heart rate.
Posaconazole prevents Aspergillus and Candida infections. You may need this medicine if you have a high risk of getting these infections. This often includes people who had a stem cell transplant or have certain blood cancers and are on chemotherapy.
Verapamil is used to treat chest pain called angina. This includes angina that happens when you are resting or during normal activity. It is also used to control your heart rate if you have a fast or irregular heartbeat, such as atrial fibrillation or atrial flutter. Verapamil also treats high blood pressure.
Posaconazole belongs to a class of drugs called azole antifungals. It works by stopping the growth of fungi. This helps your body fight off the infection.
Verapamil belongs to a class of drugs called calcium channel blockers. It works by blocking calcium from entering heart and blood vessel cells. This relaxes and widens blood vessels, which lowers blood pressure and makes it easier for the heart to pump.
- • Diarrhea
- • Nausea
- • Fever
- • Vomiting
- • Headache
- • Constipation
- • Shortness of breath
- • Dizziness
- • Slow heart rate (less than 50 beats per minute)
- • Nausea
- Febrile Neutropenia 1,017
- Drug Interaction 930
- Death 928
- Pyrexia 850
- Neutropenia 705
- Dyspnoea 356
- Nausea 341
- Drug Interaction 316
- Dizziness 286
- Hypotension 280
Posaconazole can interact with many other medicines. It can cause heart rhythm problems (QT prolongation). It can also cause liver problems. Tell your doctor about all the medicines you take.
You should not take this medicine if you have severe heart problems, very low blood pressure, or certain types of irregular heartbeats without a pacemaker. Talk to your doctor if you have any of these conditions.
Posaconazole may harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if posaconazole passes into breast milk, so talk to your doctor if you are breastfeeding.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if verapamil will harm your unborn baby. Verapamil can pass into breast milk, so talk to your doctor about the best way to feed your baby if you take this medicine.
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How to Read This posaconazole vs verapamil Comparison
posaconazole is classified in the Azole Antifungal drug class, while verapamil sits within the Calcium Channel Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, posaconazole has 4,430 submissions while verapamil has 1,579. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to posaconazole stops the body from clearing verapamil, which can lead to higher-than-normal levels of the drug in your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for posaconazole or verapamil.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.