What the FDA labels say about taking them together
Digoxin and posaconazole
Posaconazole's FDA label of August 3, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name posaconazole. The posaconazole label: “Interaction Drug: Digoxin; Interaction: Monitor digoxin plasma concentrations ()”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the posaconazole FDA label on DailyMed (effective August 3, 2026, Aurobindo Pharma Limited).
What does the digoxin label say about posaconazole?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name posaconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the posaconazole label say about digoxin?
Posaconazole label, drug interactionsInteraction Drug: Digoxin; Interaction: Monitor digoxin plasma concentrations ()
Source: FDA drug label (POSACONAZOLE), Aurobindo Pharma Limited, effective August 3, 2026 (SPL set f8a26673-261c-4e8e-b1e1-9e23aaf7f285), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Posaconazole | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $2.03 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once