Posaconazole and Diltiazem Interaction
Drug interaction information between Posaconazole and Diltiazem.
Posaconazole and Diltiazem have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Posaconazole and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Posaconazole blocks the enzyme that breaks down diltiazem, which can lead to higher amounts of the heart medication staying in your body.
FDA Label Information
7.11 Calcium Channel Blockers Metabolized by CYP3A4 Posaconazole may increase the plasma concentrations of calcium channel blockers metabolized by CYP3A4 (e.g., verapamil, diltiazem, nifedipine, nicardipine, felodipine).
Posaconazole Also Interacts With
- Esomeprazole major
- Digoxin major
- Cimetidine major
- Metoclopramide major
- Phenytoin major
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Posaconazole + Diltiazem?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Posaconazole's 27. In the minor band specifically: Posaconazole has 17 (also Alprazolam, Glipizide, Nifedipine, Verapamil); Diltiazem has 35 (also Buspirone, Pravastatin, Lovastatin, Cyclosporine).
What mechanism field is on file for Posaconazole and Diltiazem?
Posaconazole blocks the enzyme that breaks down diltiazem, which can lead to higher amounts of the heart medication staying in your body.
Posaconazole carries more major-labeled pairs than Diltiazem
SPL source-record counts only. This page's band is minor · classes on file: Posaconazole (Azole Antifungal); Diltiazem (Calcium Channel Blocker).
Posaconazole has 5 major-labeled pairs vs Diltiazem's 4. This page itself is in the minor band, not the major band.
5 major · 5 moderate · 17 minor · 27 total
- Other minor peers for Posaconazole
- Alprazolam
- Glipizide
- Nifedipine
- Verapamil
4 major · 7 moderate · 35 minor · 46 total
- Other minor peers for Diltiazem
- Buspirone
- Pravastatin
- Lovastatin
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.