Posaconazole and Alprazolam Interaction
Drug interaction information between Posaconazole and Alprazolam.
Posaconazole and Alprazolam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Posaconazole and Alprazolam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Posaconazole slows down the process your body uses to get rid of alprazolam, which can cause the sedative to build up to higher levels in your blood.
FDA Label Information
Concomitant use of posaconazole and other benzodiazepines metabolized by CYP3A4 (e.g., alprazolam, triazolam) could result in increased plasma concentrations of these benzodiazepines.
Posaconazole Also Interacts With
- Esomeprazole major
- Digoxin major
- Cimetidine major
- Metoclopramide major
- Phenytoin major
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Digoxin moderate
- Aprepitant moderate
Frequently Asked Questions
What SPL severity band is on file for Posaconazole + Alprazolam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Posaconazole and Alprazolam tie at 27 labeled pairs each. minor-band counts: Posaconazole 17 alongside Glipizide, Diltiazem, Nifedipine, Verapamil; Alprazolam 20 alongside Tramadol, Oxycodone, Morphine, Carbamazepine.
What mechanism field is on file for Posaconazole and Alprazolam?
Posaconazole slows down the process your body uses to get rid of alprazolam, which can cause the sedative to build up to higher levels in your blood.
Posaconazole carries more major-labeled pairs than Alprazolam
SPL source-record counts only. This page's band is minor · classes on file: Posaconazole (Azole Antifungal); Alprazolam (Benzodiazepine).
Posaconazole has 5 major-labeled pairs vs Alprazolam's 0. This page itself is in the minor band, not the major band.
5 major · 5 moderate · 17 minor · 27 total
- Other minor peers for Posaconazole
- Glipizide
- Diltiazem
- Nifedipine
- Verapamil
0 major · 7 moderate · 20 minor · 27 total
- Other minor peers for Alprazolam
- Tramadol
- Oxycodone
- Morphine
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.