Verapamil and Clarithromycin Interaction
Drug interaction information between Verapamil and Clarithromycin.
Verapamil and Clarithromycin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Verapamil and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these drugs can lead to dangerously low blood pressure and a very slow heartbeat. It can also cause a harmful buildup of acid in your blood.
FDA Label Information
Calcium Channel Blockers: Verapamil Use With Caution Verapamil: Hypotension, bradyarrhythmias, and lactic acidosis have been observed in patients receiving concurrent verapamil, [see Warnings and Precautions ( 5.4 )] .
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Lovastatin moderate
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Verapamil + Clarithromycin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Verapamil's 57. In the moderate band specifically: Verapamil has 6 (also Lovastatin, Metoprolol, Midazolam, Nirmatrelvir/Ritonavir); Clarithromycin has 35 (also Omeprazole, Methylprednisolone, Sildenafil, Valproate).
What mechanism field is on file for Verapamil and Clarithromycin?
Combining these drugs can lead to dangerously low blood pressure and a very slow heartbeat. It can also cause a harmful buildup of acid in your blood.
Clarithromycin carries more major-labeled pairs than Verapamil
SPL source-record counts only. This page's band is moderate · classes on file: Verapamil (Calcium Channel Blocker); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Verapamil's 4. This page itself is in the moderate band, not the major band.
4 major · 6 moderate · 47 minor · 57 total
- Other moderate peers for Verapamil
- Lovastatin
- Metoprolol
- Midazolam
- Nirmatrelvir/Ritonavir
16 major · 35 moderate · 30 minor · 81 total
- Other moderate peers for Clarithromycin
- Omeprazole
- Methylprednisolone
- Sildenafil
- Valproate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.