Verapamil and Eplerenone Interaction
Drug interaction information between Verapamil and Eplerenone.
Verapamil and Eplerenone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Verapamil and Eplerenone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Verapamil slows down the body's ability to process eplerenone, which can cause the drug to reach higher levels in your blood.
What To Do
Your doctor should limit your eplerenone dose to 25 mg once daily when taking these together.
FDA Label Information
7 DRUG INTERACTIONS • CYP3A Inhibitors: In post-MI HFrEF patients, do not exceed 25 mg once daily when used with moderate CYP3A inhibitors (e.g., verapamil, erythromycin, saquinavir, fluconazole).
Verapamil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
- Lovastatin moderate
Eplerenone Also Interacts With
- Fluconazole major
- Erythromycin major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Lithium minor
Frequently Asked Questions
Can I take Verapamil and Eplerenone together?
This is a major interaction. Your doctor should limit your eplerenone dose to 25 mg once daily when taking these together.
How serious is the interaction between Verapamil and Eplerenone?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Verapamil and Eplerenone interact?
Verapamil slows down the body's ability to process eplerenone, which can cause the drug to reach higher levels in your blood.
Understanding the Verapamil and Eplerenone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Verapamil belongs to the Calcium Channel Blocker class and Eplerenone belongs to the Aldosterone Antagonist class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Verapamil slows down the body's ability to process eplerenone, which can cause the drug to reach higher levels in your blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Verapamil has 57 total documented interactions on file in this dataset, and Eplerenone has 12. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should limit your eplerenone dose to 25 mg once daily when taking these together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Verapamil or Eplerenone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.