Verapamil and Eplerenone Interaction
Drug interaction information between Verapamil and Eplerenone.
Verapamil and Eplerenone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Verapamil and Eplerenone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Verapamil slows down the body's ability to process eplerenone, which can cause the drug to reach higher levels in your blood.
FDA Label Information
7 DRUG INTERACTIONS • CYP3A Inhibitors: In post-MI HFrEF patients, do not exceed 25 mg once daily when used with moderate CYP3A inhibitors (e.g., verapamil, erythromycin, saquinavir, fluconazole).
Verapamil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
- Lovastatin moderate
Eplerenone Also Interacts With
- Fluconazole major
- Erythromycin major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Lithium minor
Frequently Asked Questions
What SPL severity band is on file for Verapamil + Eplerenone?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Eplerenone's 12. In the major band specifically: Verapamil has 4 (also Ezetimibe, Ezetimibe/Simvastatin, Simvastatin); Eplerenone has 5 (also Fluconazole, Erythromycin, Itraconazole, Nirmatrelvir/Ritonavir).
What mechanism field is on file for Verapamil and Eplerenone?
Verapamil slows down the body's ability to process eplerenone, which can cause the drug to reach higher levels in your blood.
Eplerenone carries more major-labeled pairs than Verapamil
SPL source-record counts only. This page's band is major · classes on file: Verapamil (Calcium Channel Blocker); Eplerenone (Aldosterone Antagonist).
Eplerenone has 5 major-labeled pairs vs Verapamil's 4.
4 major · 6 moderate · 47 minor · 57 total
- Other major peers for Verapamil
- Ezetimibe
- Ezetimibe/Simvastatin
- Simvastatin
5 major · 0 moderate · 7 minor · 12 total
- Other major peers for Eplerenone
- Fluconazole
- Erythromycin
- Itraconazole
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.