What the FDA labels say about taking them together
Esomeprazole and posaconazole
Posaconazole's FDA label of August 3, 2026 names esomeprazole in its drug interactions section; the esomeprazole labels PlainMeds reads (3) do not name posaconazole. The posaconazole label: “Interaction Drug: Rifabutin, phenytoin, efavirenz, cimetidine, esomeprazole*; Interaction: Avoid coadministration unless the benefit outweighs the risks”
Check it at the source: the esomeprazole FDA label on DailyMed (effective March 19, 2024, Haleon US Holdings LLC); the posaconazole FDA label on DailyMed (effective August 3, 2026, Aurobindo Pharma Limited).
What does the esomeprazole label say about posaconazole?
Esomeprazole's label (effective March 19, 2024) and its 2 other brand-application labels do not name posaconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nexium 24HR), NDA204655 (Astrazeneca Lp), as published by Haleon US Holdings LLC, effective March 19, 2024 (SPL set 4513934d-0cf0-40fc-a348-b4e75a33b094), via openFDA; the full label on DailyMed
What does the posaconazole label say about esomeprazole?
Posaconazole label, drug interactionsInteraction Drug: Rifabutin, phenytoin, efavirenz, cimetidine, esomeprazole*; Interaction: Avoid coadministration unless the benefit outweighs the risks (,)
Noxafil label (Merck Sharp & Dohme LLC, February 13, 2026), drug interactionsInteraction Drug: Rifabutin, phenytoin, efavirenz, cimetidine, esomeprazole The drug interactions with esomeprazole and metoclopramide do not apply to Noxafil tablets or Noxafil PowderMix (,).; Interaction: Avoid coadministration unless the benefit outweighs the risks (,)
Source: FDA drug label (Noxafil, NDA022003), Merck Sharp & Dohme LLC, effective February 13, 2026 (SPL set b073b082-7b57-4423-8c06-4fd4263d6f84), via openFDA
Source: FDA drug label (POSACONAZOLE), Aurobindo Pharma Limited, effective August 3, 2026 (SPL set f8a26673-261c-4e8e-b1e1-9e23aaf7f285), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Esomeprazole | Posaconazole | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.145 per capsule 20 mg capsule | $2.03 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once