Posaconazole and Esomeprazole Interaction
Drug interaction information between Posaconazole and Esomeprazole.
Posaconazole and Esomeprazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Posaconazole and Esomeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Esomeprazole changes the acid levels in the stomach, which can prevent certain forms of posaconazole from being absorbed into the body. This may make the antifungal treatment less effective.
FDA Label Information
Interaction Drug Interaction Rifabutin, phenytoin, efavirenz, cimetidine, esomeprazole* Avoid coadministration unless the benefit outweighs the risks ( 7.6 , 7.7 , 7.8 , 7.9 ) Other drugs metabolized by CYP3A4 Consider dosage adjustment and monitor for adverse effects and toxicity ( 7.1 , 7.10 , 7.11 ) Digoxin Monitor digoxin plasma concentrations ( 7.12 ) Fosamprenavir, metoclopramide* Monitor for breakthrough fungal infections ( 7.6 , 7.13 ) *The drug interactions with esomeprazole and metoclopramide do not apply to posaconazole tablets.
Posaconazole Also Interacts With
- Digoxin major
- Cimetidine major
- Metoclopramide major
- Phenytoin major
- Efavirenz/Emtricitabine/Tenofovir moderate
Esomeprazole Also Interacts With
- Clopidogrel moderate
- Digoxin minor
- Risedronate minor
Frequently Asked Questions
What SPL severity band is on file for Posaconazole + Esomeprazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Posaconazole has 27 labeled pairs on file vs Esomeprazole's 4. In the major band specifically: Posaconazole has 5 (also Digoxin, Cimetidine, Metoclopramide, Phenytoin); Esomeprazole has 1.
What mechanism field is on file for Posaconazole and Esomeprazole?
Esomeprazole changes the acid levels in the stomach, which can prevent certain forms of posaconazole from being absorbed into the body. This may make the antifungal treatment less effective.
Posaconazole carries more major-labeled pairs than Esomeprazole
SPL source-record counts only. This page's band is major · classes on file: Posaconazole (Azole Antifungal); Esomeprazole (Proton Pump Inhibitor (PPI)).
Posaconazole has 5 major-labeled pairs vs Esomeprazole's 1.
5 major · 5 moderate · 17 minor · 27 total
- Other major peers for Posaconazole
- Digoxin
- Cimetidine
- Metoclopramide
- Phenytoin
1 major · 1 moderate · 2 minor · 4 total
Esomeprazole has no other major-band peer in this dataset besides Posaconazole.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.