Verapamil and Timolol Interaction
Drug interaction information between Verapamil and Timolol.
Verapamil and Timolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Verapamil and Timolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Even as eye drops, timolol can combine with verapamil to significantly slow down your heart rate.
FDA Label Information
Asymptomatic bradycardia (36 beats/min) with a wandering atrial pacemaker has been observed in a patient receiving concomitant timolol (a beta-adrenergic blocker) eyedrops and oral verapamil.
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Timolol Also Interacts With
- Dorzolamide moderate
- Clonidine minor
- Brimonidine/Timolol minor
- Darunavir minor
- Dorzolamide/Timolol minor
Frequently Asked Questions
What SPL severity band is on file for Verapamil + Timolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Timolol's 6. In the minor band specifically: Verapamil has 47 (also Atorvastatin, Aspirin, Atenolol, Cyclosporine); Timolol has 5 (also Clonidine, Brimonidine/Timolol, Darunavir, Dorzolamide/Timolol).
What mechanism field is on file for Verapamil and Timolol?
Even as eye drops, timolol can combine with verapamil to significantly slow down your heart rate.
Verapamil carries more major-labeled pairs than Timolol
SPL source-record counts only. This page's band is minor · classes on file: Verapamil (Calcium Channel Blocker); Timolol (Beta-Blocker (Ophthalmic)).
Verapamil has 4 major-labeled pairs vs Timolol's 0. This page itself is in the minor band, not the major band.
4 major · 6 moderate · 47 minor · 57 total
- Other minor peers for Verapamil
- Atorvastatin
- Aspirin
- Atenolol
- Cyclosporine
0 major · 1 moderate · 5 minor · 6 total
- Other minor peers for Timolol
- Clonidine
- Brimonidine/Timolol
- Darunavir
- Dorzolamide/Timolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.