diltiazem vs posaconazole
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Side-by-side comparison of diltiazem and posaconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.11 Calcium Channel Blockers Metabolized by CYP3A4 Posaconazole may increase the plasma concentrations of calcium channel blockers metabolized by CYP3A4 (e.g., verapamil, diltiazem, nifedipine, nicardipine, felodipine).
Cardizem, Tiazac
Noxafil
Diltiazem is a medicine that helps lower high blood pressure and prevent chest pain. It belongs to a class of drugs called calcium channel blockers.
Posaconazole is an antifungal medicine. It helps prevent certain fungal infections in people with weakened immune systems.
Diltiazem is used to treat high blood pressure. It can be used alone or with other blood pressure medicines. Diltiazem also helps manage chronic stable angina (chest pain) and angina caused by spasms in the heart's blood vessels.
Posaconazole prevents Aspergillus and Candida infections. You may need this medicine if you have a high risk of getting these infections. This often includes people who had a stem cell transplant or have certain blood cancers and are on chemotherapy.
Diltiazem works by relaxing blood vessels, which lowers blood pressure. It also reduces the heart's workload, which can prevent chest pain. This medicine blocks calcium from entering heart and blood vessel cells.
Posaconazole belongs to a class of drugs called azole antifungals. It works by stopping the growth of fungi. This helps your body fight off the infection.
- • Swelling in your ankles or feet
- • Headache
- • Dizziness
- • Slow heart rate
- • Constipation
- • Diarrhea
- • Nausea
- • Fever
- • Vomiting
- • Headache
- Dyspnoea 3,202
- Fatigue 2,638
- Nausea 2,372
- Pain 2,365
- Dizziness 2,091
- Febrile Neutropenia 1,017
- Drug Interaction 930
- Death 928
- Pyrexia 850
- Neutropenia 705
Diltiazem can interact with other heart medications. Tell your doctor if you take beta-blockers or digoxin. Using diltiazem with these drugs can cause heart problems. Your doctor may need to adjust your dosages.
Posaconazole can interact with many other medicines. It can cause heart rhythm problems (QT prolongation). It can also cause liver problems. Tell your doctor about all the medicines you take.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if diltiazem will harm your unborn baby. Diltiazem passes into breast milk, so talk to your doctor about breastfeeding while taking this medicine.
Posaconazole may harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if posaconazole passes into breast milk, so talk to your doctor if you are breastfeeding.
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How to Read This diltiazem vs posaconazole Comparison
diltiazem is classified in the Calcium Channel Blocker drug class, while posaconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, diltiazem has 12,668 submissions while posaconazole has 4,430. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to posaconazole blocks the enzyme that breaks down diltiazem, which can lead to higher amounts of the heart medication staying in your body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for diltiazem or posaconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.